PMID- 11711679
OWN - NLM
STAT- MEDLINE
DCOM- 20020205
LR  - 20210102
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 294
IP  - 5546
DP  - 2001 Nov 16
TI  - Induction of dendritic cell differentiation by IFN-alpha in systemic lupus 
      erythematosus.
PG  - 1540-3
AB  - Dendritic cells (DCs) are important in regulating both immunity and tolerance. 
      Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune 
      disease characterized by autoreactive B and T cells, may be caused by alterations 
      in the functions of DCs. Consistent with this, monocytes from SLE patients' blood 
      were found to function as antigen-presenting cells, in vitro. Furthermore, serum 
      from SLE patients induced normal monocytes to differentiate into DCs. These DCs 
      could capture antigens from dying cells and present them to CD4-positive T cells. 
      The capacity of SLE patients' serum to induce DC differentiation correlated with 
      disease activity and depended on the actions of interferon-alpha (IFN-alpha). 
      Thus, unabated induction of DCs by IFN-alpha may drive the autoimmune response in 
      SLE.
FAU - Blanco, P
AU  - Blanco P
AD  - Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
FAU - Palucka, A K
AU  - Palucka AK
FAU - Gill, M
AU  - Gill M
FAU - Pascual, V
AU  - Pascual V
FAU - Banchereau, J
AU  - Banchereau J
LA  - eng
GR  - R01 AR46589/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, CD)
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Adolescent
MH  - Antigen Presentation
MH  - Antigens, CD/analysis
MH  - Blood Cell Count
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Child
MH  - Dendritic Cells/*cytology/*immunology
MH  - Homeostasis
MH  - Humans
MH  - Interferon-alpha/blood/pharmacology/*physiology
MH  - Lupus Erythematosus, Systemic/blood/*immunology
MH  - Lymphocyte Culture Test, Mixed
MH  - Monocytes/cytology/*immunology
EDAT- 2001/11/17 10:00
MHDA- 2002/02/06 10:01
CRDT- 2001/11/17 10:00
PHST- 2001/11/17 10:00 [pubmed]
PHST- 2002/02/06 10:01 [medline]
PHST- 2001/11/17 10:00 [entrez]
AID - 294/5546/1540 [pii]
AID - 10.1126/science.1064890 [doi]
PST - ppublish
SO  - Science. 2001 Nov 16;294(5546):1540-3. doi: 10.1126/science.1064890.