PMID- 11711864
OWN - NLM
STAT- MEDLINE
DCOM- 20020219
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 12
IP  - 15
DP  - 2001 Oct 29
TI  - The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile 
      seizures.
PG  - 3243-6
AB  - In this study we investigated the expression of brain-derived neurotrophic factor 
      (BDNF) and c-fos mRNA in the hippocampal formation after febrile seizures (FSs) 
      with in situ hybridization histochemistry using riboprobes. The induction of BDNF 
      mRNA was firstly observed in the dentate gyrus at 30 min after FSs. The 
      expression in the dentate gyrus peaked at 3 h and returned to basal level at 24 
      h. It was also observed in the CA3 of hippocampus from 2 to 3 h. The induction of 
      c-fos mRNA was observed in the dentate gyrus at 30 min and 1 h. These 
      observations suggest that BDNF and c-fos are the genes whose expression can be 
      altered by FSs and might be related to pathologic alterations after FSs.
FAU - Kim, Y H
AU  - Kim YH
AD  - Department of Pediatrics, College of Medicine, Catholic University of Korea, 505 
      Banpo-dong, Socho-gu, Seoul 137-701, Korea.
FAU - Rhyu, I J
AU  - Rhyu IJ
FAU - Park, K W
AU  - Park KW
FAU - Eun, B L
AU  - Eun BL
FAU - Kim, Y I
AU  - Kim YI
FAU - Rha, H K
AU  - Rha HK
FAU - Kim, D S
AU  - Kim DS
FAU - Jo, Y H
AU  - Jo YH
FAU - Whang, K T
AU  - Whang KT
FAU - Kim, M S
AU  - Kim MS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dentate Gyrus/metabolism/physiopathology
MH  - Gene Expression Regulation/*physiology
MH  - Hippocampus/*metabolism/physiopathology
MH  - Hyperthermia, Induced
MH  - Male
MH  - Neuronal Plasticity/genetics
MH  - Neurons/*metabolism
MH  - Proto-Oncogene Proteins c-fos/*genetics
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seizures, Febrile/genetics/*metabolism/physiopathology
MH  - Up-Regulation/genetics
EDAT- 2001/11/17 10:00
MHDA- 2002/02/20 10:01
CRDT- 2001/11/17 10:00
PHST- 2001/11/17 10:00 [pubmed]
PHST- 2002/02/20 10:01 [medline]
PHST- 2001/11/17 10:00 [entrez]
AID - 10.1097/00001756-200110290-00020 [doi]
PST - ppublish
SO  - Neuroreport. 2001 Oct 29;12(15):3243-6. doi: 10.1097/00001756-200110290-00020.