PMID- 11712767
OWN - NLM
STAT- MEDLINE
DCOM- 20020404
LR  - 20190921
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 46
IP  - 5
DP  - 2001 Nov
TI  - Herbal medicines, Sairei-to and Tokishakuyaku-san, differently modulate the 
      release of cytokines from decidual versus peripheral blood mononuclear cells.
PG  - 369-72
AB  - PROBLEM AND METHOD OF STUDY: We have shown that Tokishakuyaku-san (Toki) and 
      Sairei-to (Sai) enhance T helper-1 (Th1) cytokine release from peripheral blood 
      mononuclear cells (PBMCs): thereby, they could be a therapeutic means in the 
      treatment of autoimmunity related recurrent abortion in which T helper-2 (Th2) 
      polarization is exaggerated, the condition purported to benefit from these herbal 
      medicines. However, an open question is whether these medicines might enhance Th1 
      cytokine release in decidual tissues and thereby stimulate the killer activity, 
      thus, working counterproductively by accelerating maternal alloimmune reactions 
      toward fetal tissues. To address this, we examined the effects of these medicines 
      on the release of cytokines from decidual mononuclear cells (DMCs) in comparison 
      with PBMCs on the assumption that they might act differently on these cell types. 
      The effects of these medicines were investigated as related to human leukocyte 
      antigen (HLA)-G, a nonclassical HLA class I antigen expressed on trophoblasts and 
      a putative crucial player involved in fetomaternal immune interplay. RESULTS: 
      Regarding Th1 cytokines. Toki marginally increased the release of tumor necrosis 
      factor (TNF)-alpha, but not interferon (IFN)-gamma from DMCs while Sai did not 
      affect the release of both. Both Toki and Sai were without effect in modulating 
      the release of interleukin (IL)-4, a member of Th2 cytokines. Interestingly, the 
      presence of HLA-G reduced the release of Th1 cytokines from DMCs regardless of 
      the addition of Toki, Sai or none. These findings are in sharp contrast with 
      PBMCs on which these medicines seem to act so as to enhance Th1 polarization and 
      attenuate Th2 polarization. CONCLUSION: Differential effects of Toki and Sai on 
      the release of Th1/Th2 cytokines between DMCs and PBMCs may afford the rationale 
      of these medicines in the treatment of autoimmunity-related recurrent abortion.
FAU - Fujii, O
AU  - Fujii O
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, University of 
      Tokyo, Japan. fujiit-tky@umin.ac.jp
FAU - Kanai, T
AU  - Kanai T
FAU - Kouzuma, S
AU  - Kouzuma S
FAU - Baba, K
AU  - Baba K
FAU - Miki, A
AU  - Miki A
FAU - Hyodo, H
AU  - Hyodo H
FAU - Yamashita, T
AU  - Yamashita T
FAU - Unno, N
AU  - Unno N
FAU - Taketani, Y
AU  - Taketani Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (sairei-to)
RN  - 0 (toki-shakuyaku-san)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Cell Line
MH  - Cytokines/*biosynthesis
MH  - Decidua/*drug effects/immunology
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Female
MH  - HLA Antigens/physiology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/physiology
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-4/biosynthesis
MH  - Leukocytes, Mononuclear/*drug effects/immunology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 2001/11/20 10:00
MHDA- 2002/04/18 10:01
CRDT- 2001/11/20 10:00
PHST- 2001/11/20 10:00 [pubmed]
PHST- 2002/04/18 10:01 [medline]
PHST- 2001/11/20 10:00 [entrez]
AID - 10.1034/j.1600-0897.2001.d01-26.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2001 Nov;46(5):369-72. doi: 
      10.1034/j.1600-0897.2001.d01-26.x.