PMID- 11713634
OWN - NLM
STAT- MEDLINE
DCOM- 20020111
LR  - 20191210
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 141
IP  - 2
DP  - 2001 Nov
TI  - Cutaneomotor integration in human hand motor areas: somatotopic effect and 
      interaction of afferents.
PG  - 232-41
AB  - The aim of this study was to elucidate sensorimotor integration in human hand 
      motor areas, its time course, somatotopy and the interaction of sensory fields 
      arising from two different fingers. We studied the influence of different 
      intensities of electrical digital stimulation of two different fingers on 
      motor-evoked potentials elicited in hand muscles by transcranial magnetic 
      stimulation (TMS). Single conditioning electrical stimuli were applied to the 
      right second (D2) and fifth fingers (D5) individually and also to both fingers 
      (D2+D5) simultaneously in six normal volunteers. Magnetic tests, adjusted to 
      produce a response in the abductor digiti minimi muscle of the right hand, were 
      delivered using a circular and a focal coil. The digital stimuli were delivered 
      to the finger at the sensory threshold (ST), at 3 and 5 times the ST, and over 
      the pain threshold at interstimulus intervals (ISIs) ranging from 10 to 100 ms. 
      In order to define the anatomical level of the sensorimotor interactions, the 
      effect of the digital stimulation on TMS was compared to the effect on 
      transcranial electrical stimulation. When the peripheral stimulation was 
      delivered at the ST a small inhibitory effect was found only when stimulating 
      both fingers. At 3 times the ST we detected a topographic distribution of 
      motor-evoked potential inhibition, which partially disappeared at higher 
      intensity (5 times the ST); two types of convergence effects took place at 
      different ISIs. When conditioning stimuli were painful, somatotopy and 
      convergence were lost. Sensorimotor integration shows somatotopy and interaction 
      of afferents at different sites. The intensity of the conditioning stimulus plays 
      an important role in topography and sensory convergence. The importance of these 
      mechanisms in physiology and physiopathology is discussed.
FAU - Tamburin, S
AU  - Tamburin S
AD  - Department of Neurological Sciences and Vision, Section of Clinical Neurology, 
      University of Verona, Ospedale Policlinico G.B. Rossi, piazzale Scuro, 37134 
      Verona, Italy. s_tamburin@yahoo.com
FAU - Manganotti, P
AU  - Manganotti P
FAU - Zanette, G
AU  - Zanette G
FAU - Fiaschi, A
AU  - Fiaschi A
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Afferent Pathways/*physiology
MH  - Conditioning, Psychological/physiology
MH  - Electric Stimulation
MH  - Electroencephalography
MH  - Electromyography
MH  - Evoked Potentials, Motor/*physiology
MH  - Feedback/*physiology
MH  - Female
MH  - Fingers/*innervation/physiology
MH  - Functional Laterality/physiology
MH  - Humans
MH  - Magnetics
MH  - Male
MH  - Mechanoreceptors/*physiology
MH  - Motor Cortex/*physiology
MH  - Movement/physiology
MH  - Muscle Contraction/physiology
MH  - Muscle, Skeletal/innervation/physiology
MH  - Neural Conduction/physiology
MH  - Neural Inhibition/physiology
MH  - Pain/physiopathology
MH  - Reaction Time/physiology
MH  - Skin/innervation
MH  - Touch/*physiology
EDAT- 2001/11/20 10:00
MHDA- 2002/01/12 10:01
CRDT- 2001/11/20 10:00
PHST- 2000/10/20 00:00 [received]
PHST- 2001/07/01 00:00 [accepted]
PHST- 2001/11/20 10:00 [pubmed]
PHST- 2002/01/12 10:01 [medline]
PHST- 2001/11/20 10:00 [entrez]
AID - 10.1007/s002210100859 [doi]
PST - ppublish
SO  - Exp Brain Res. 2001 Nov;141(2):232-41. doi: 10.1007/s002210100859.