PMID- 11714011
OWN - NLM
STAT- MEDLINE
DCOM- 20011214
LR  - 20131121
IS  - 0309-3913 (Print)
IS  - 0309-3913 (Linking)
VI  - 29
IP  - 3-4
DP  - 2000 Sep-Dec
TI  - Serum and urinary magnesium during treatment of patients with chronic congestive 
      heart failure.
PG  - 301-3
AB  - Electrolyte disturbances are common in patients with Congestive Heart Failure 
      (CHF) especially during long-term treatments. Unlike potassium, little is known 
      of how magnesium is affected in these patients. This study was carried out to 
      determine the serum and urinary concentration of magnesium in patients with CHF 
      who were treated with lisinopril [Angiotensin-Converting Enzyme Inhibitor 
      (ACEI)], frusemide (diuretic) and digoxin, at baseline, 2 weeks and 4 weeks. 45 
      patients (Group I; 24 male, 21 female; average age 49.7 years) with CHF, New York 
      Heart Association (NYHA) Class II, III were matched with 45 healthy controls 
      (Group II; 24 male, 21 female, average age 49.3 years). Serum and urinary 
      magnesium were assayed by atomic absorption spectrophotometer. Statistical 
      analysis was made by Student's t-test. At baseline, serum magnesium concentration 
      in CHF patients was not significantly lower than in controls, p > 0.1. However, a 
      higher loss of magnesium in urine was found in CHF patients compared with control 
      subjects at baseline, p < 0.01. Serum magnesium concentration decreased 
      significantly during treatment except in CHF patients on lisinopril, p < 0.05. 
      The lowest excretion of magnesium was also found in this group of patients. Our 
      study shows that lisinopril is magnesium-sparing in patients with CHF.
FAU - Oladapo, O O
AU  - Oladapo OO
AD  - Department of Anatomy, College of Medicine, University of Ibadan, Nigeria.
FAU - Falase, A O
AU  - Falase AO
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - Afr J Med Med Sci
JT  - African journal of medicine and medical sciences
JID - 7801013
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Diuretics)
RN  - 73K4184T59 (Digoxin)
RN  - 7LXU5N7ZO5 (Furosemide)
RN  - E7199S1YWR (Lisinopril)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiotensin-Converting Enzyme Inhibitors/*adverse effects
MH  - Cardiotonic Agents/*adverse effects
MH  - Case-Control Studies
MH  - Digoxin/*adverse effects
MH  - Diuretics/*adverse effects
MH  - Female
MH  - Furosemide/*adverse effects
MH  - Heart Failure/classification/*complications/*drug therapy
MH  - Humans
MH  - Lisinopril/*adverse effects
MH  - Magnesium/*blood/*urine
MH  - Magnesium Deficiency/*etiology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Severity of Illness Index
MH  - Spectrophotometry, Atomic
MH  - Treatment Outcome
EDAT- 2001/11/21 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/21 10:00
PHST- 2001/11/21 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/21 10:00 [entrez]
PST - ppublish
SO  - Afr J Med Med Sci. 2000 Sep-Dec;29(3-4):301-3.