PMID- 11714081
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20190921
IS  - 0277-0903 (Print)
IS  - 0277-0903 (Linking)
VI  - 38
IP  - 7
DP  - 2001 Oct
TI  - Airway remodeling and serum total immunoglobulin E (IgE) levels in a murine model 
      of asthma.
PG  - 585-91
AB  - A murine model of allergen-induced airway inflammation, epithelial phenotypic 
      changes, and total immunoglobulin E (IgE) levels is described. Mice were 
      sensitized to ovalbumin without adjuvant and challenged by multiple intratracheal 
      instillations of ovalbumin by a nonsurgical technique. After repeated challenges, 
      the basement membrane of the airway epithelium showed fibrosis, inflammatory cell 
      infiltration at peribronchial and perivascular sites, and goblet cell 
      hyperplasia. In addition, total IgE levels were found to be increased 
      significantly. Further studies which will evaluate the contribution of each 
      feature of remodeled airway to the natural history of asthma are definitely 
      needed.
FAU - Akkoc, T
AU  - Akkoc T
AD  - Pediatric Allergy and Immunology Department, Marmara University Hospital, 
      Istanbul, Turkey. takkoc@marun.edu.tr
FAU - Tolunay, S
AU  - Tolunay S
FAU - Barlan, I
AU  - Barlan I
FAU - Basaran, M
AU  - Basaran M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
EIN - J Asthma 2002 Oct;39(7):673. Barlau I [corrected to Barlan I]
MH  - Animals
MH  - Asthma/blood/immunology/*physiopathology
MH  - Bronchi/immunology/pathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Immunoglobulin E/*blood
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
EDAT- 2001/11/21 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/21 10:00
PHST- 2001/11/21 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/21 10:00 [entrez]
AID - 10.1081/jas-100107123 [doi]
PST - ppublish
SO  - J Asthma. 2001 Oct;38(7):585-91. doi: 10.1081/jas-100107123.