PMID- 11714537
OWN - NLM
STAT- MEDLINE
DCOM- 20030610
LR  - 20190921
IS  - 0169-5002 (Print)
IS  - 0169-5002 (Linking)
VI  - 34
IP  - 3
DP  - 2001 Dec
TI  - Analysis of HLA-class-I specific natural killer cell receptors expressed on T 
      lymphocytes infiltrating non-small-cell lung cancer.
PG  - 395-405
AB  - HLA-class I-specific natural killer cell receptors (HNKR) have been described to 
      significantly interfere with both specific and non-specific functional activities 
      of T lymphocytes. Despite the clear evidences obtained in T cells derived from 
      peripheral blood, little is known about the activity of HNKR expressed in tumor 
      infiltrating lymphocytes. For this reason, we have studied T lymphocytes derived 
      from advanced non small cell lung cancers (NSCLC). The population of T cells 
      expressing the HNKR(+) phenotype was rare both in NSCLC-associated lymphocytes 
      and in the peripheral blood. The two populations were clearly oligoclonal, as 
      shown by the analysis of T cell receptor repertoire. Interestingly, while HNKR(+) 
      T cells derived from the peripheral blood belonged to the CD45R0 phenotype, the 
      large majority of HNKR(+) T cells in TIL were CD45RA. Functionally, all HNKR(+) T 
      cells displayed a cytolytic activity against allogeneic NSCLC. Autologous NSCLC, 
      tested in a single patient, was lysed efficiently by HNKR(+) T cells, thus 
      suggesting that at least in this model, the presence of HNKR did not 
      significantly interfere with the functional capacity of effector cells.
FAU - Semino, C
AU  - Semino C
AD  - Laboratorio di Immunoterapia Cellulare, Istituto Nazionale per la Ricerca sul 
      Cancro Largo Rosanna Benzi 10, 16132 Genova, Italy.
FAU - Ferlazzo, G
AU  - Ferlazzo G
FAU - Ratto, G B
AU  - Ratto GB
FAU - Melioli, G
AU  - Melioli G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Lung Cancer
JT  - Lung cancer (Amsterdam, Netherlands)
JID - 8800805
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Antigen, T-Cell)
SB  - IM
MH  - Aged
MH  - Antigens, Neoplasm/chemistry/*immunology
MH  - Carcinoma, Non-Small-Cell Lung/*immunology
MH  - Flow Cytometry
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Lung Neoplasms/*immunology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Receptors, Antigen, T-Cell/*immunology
MH  - T-Lymphocytes, Cytotoxic/*chemistry/immunology
EDAT- 2001/11/21 10:00
MHDA- 2003/06/11 05:00
CRDT- 2001/11/21 10:00
PHST- 2001/11/21 10:00 [pubmed]
PHST- 2003/06/11 05:00 [medline]
PHST- 2001/11/21 10:00 [entrez]
AID - S0169-5002(01)00272-0 [pii]
AID - 10.1016/s0169-5002(01)00272-0 [doi]
PST - ppublish
SO  - Lung Cancer. 2001 Dec;34(3):395-405. doi: 10.1016/s0169-5002(01)00272-0.