PMID- 11714792
OWN - NLM
STAT- MEDLINE
DCOM- 20020102
LR  - 20190515
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 167
IP  - 11
DP  - 2001 Dec 1
TI  - Kinetics of antigen-induced phenotypic and functional maturation of human 
      monocyte-derived dendritic cells.
PG  - 6286-91
AB  - Dendritic cells (DCs), a critical component of innate immunity, are the most 
      potent APCs. When DCs mature, they can elicit strong T cell responses. We studied 
      the kinetics of Ag-induced phenotypic and functional maturation of human 
      monocyte-derived DCs using an in vitro T cell-independent culture system. With 
      this model, we herein show that an Ag that has recently or repetitively been 
      exposed ("exposed Ag") rapidly induces a high level of maturation; however, an Ag 
      that has never or only remotely been exposed ("unexposed Ag") slowly induces a 
      low level of maturation. The kinetics of Ag-induced maturation of DCs possibly 
      implies a novel mechanism for immunological memory that would provide maximal 
      host protection from repetitively invading pathogens in the environment.
FAU - Hsieh, S M
AU  - Hsieh SM
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan. hsmaids@hotmail.com
FAU - Pan, S C
AU  - Pan SC
FAU - Hung, C C
AU  - Hung CC
FAU - Tsai, H C
AU  - Tsai HC
FAU - Chen, M Y
AU  - Chen MY
FAU - Lee, C N
AU  - Lee CN
FAU - Chang, S C
AU  - Chang SC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, T-Independent)
RN  - 0 (Antigens, Viral)
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Biomarkers)
RN  - 0 (CD40 Antigens)
RN  - 0 (CD86 protein, human)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Antigens, CD/analysis/biosynthesis
MH  - Antigens, T-Independent/*physiology
MH  - Antigens, Viral/physiology
MH  - B7-1 Antigen/analysis/biosynthesis
MH  - B7-2 Antigen
MH  - Biomarkers/analysis
MH  - CD40 Antigens/analysis/biosynthesis
MH  - Cell Cycle/*immunology
MH  - Cell Differentiation/immunology
MH  - Cells, Cultured
MH  - Cytomegalovirus/immunology
MH  - Dendritic Cells/*cytology/*immunology/metabolism
MH  - HLA-DR Antigens/analysis/biosynthesis
MH  - Humans
MH  - *Immunophenotyping
MH  - *Lymphocyte Activation
MH  - Lymphocyte Depletion
MH  - Membrane Glycoproteins/analysis/biosynthesis
MH  - Models, Immunological
MH  - Monocytes/*cytology/*immunology/metabolism
MH  - Time Factors
EDAT- 2001/11/21 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/21 10:00
PHST- 2001/11/21 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/21 10:00 [entrez]
AID - 10.4049/jimmunol.167.11.6286 [doi]
PST - ppublish
SO  - J Immunol. 2001 Dec 1;167(11):6286-91. doi: 10.4049/jimmunol.167.11.6286.