PMID- 11716176
OWN - NLM
STAT- MEDLINE
DCOM- 20020312
LR  - 20191210
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 18
IP  - 4
DP  - 2001 Oct
TI  - Lung dendritic cells and host immunity to infection.
PG  - 692-704
AB  - The lung is a portal of entry for numerous microbial pathogens, against which 
      evolution has created an adequate innate and adaptive immune response. Dendritic 
      cells (DCs) are central to the integration of innate and specific immunity. These 
      cells are located within the epithelium and interstitium of the lung where they 
      are influenced by the innate immune system. Upon recognition and internalization 
      of microbial antigens, DCs migrate to the draining lymph nodes of the lung to 
      initiate the specific cellular and humoral immune response. By their capacity to 
      integrate stimuli derived from the pathogen, the host and the environment, they 
      are specialized to induce a protective immune response while at the same time 
      avoiding damage to the host. It is becoming increasingly clear that dendritic 
      cells are involved in the induction of immunity to viruses, bacteria, 
      mycobacteria and fungi. Some pathogens subvert the function of dendritic cells to 
      escape immune recognition. Not surprisingly, if dendritic cell function fails, 
      the consequence for the host is immunodeficiency.
FAU - Lambrecht, B N
AU  - Lambrecht BN
AD  - Dept of Pulmonary and Critical Care Medicine, Erasmus Medical Centre Rotterdam, 
      The Netherlands.
FAU - Prins, J B
AU  - Prins JB
FAU - Hoogsteden, H C
AU  - Hoogsteden HC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/immunology
MH  - Cytokines/immunology/metabolism
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Immunity, Innate
MH  - Infections/*immunology
MH  - Inflammation/immunology/microbiology
MH  - Lung/cytology/*immunology
MH  - T-Lymphocytes/immunology
RF  - 89
EDAT- 2001/11/22 10:00
MHDA- 2002/03/13 10:01
CRDT- 2001/11/22 10:00
PHST- 2001/11/22 10:00 [pubmed]
PHST- 2002/03/13 10:01 [medline]
PHST- 2001/11/22 10:00 [entrez]
PST - ppublish
SO  - Eur Respir J. 2001 Oct;18(4):692-704.