PMID- 11717892
OWN - NLM
STAT- MEDLINE
DCOM- 20011221
LR  - 20061115
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 33
IP  - 4
DP  - 1998 Aug
TI  - [Study on the effect of human herpesvirus 6 on replication of Epstein-Barr 
      virus].
PG  - 235-6
AB  - OBJECTIVE: To examine the effect of human herpesvirus 6(HHV-6) on the replication 
      of Epstein-Barr virus (EBV) in cell lines. METHODS: Both EBV-infected Raji cells 
      and EBV-transformed lymphoblastoid cell lines (LCL) were infected with HHV-6. 
      Immunofluoresence assay (IFA) with monoclonal antibodies (MAb) against HHV-6 was 
      applied to confirm the infection of HHV-6 in the two cell lines. Expression of 
      EBV antigen was examined by IFA using human anti-EBV serum. RESULTS: Following 
      HHV-6 infection, cytopathic effects (CPE) were observed in Raji cells but not in 
      LCL. HHV-6 were detected in both cell lines by IFA with anti-HHV-6 MAb, but not 
      in controls. EBV antigens were detected by IFA with human serum against EBV in 
      both HHV-6 infected cell lines. CONCLUSION: Data in this study suggest that HHV-6 
      promotes the expression of EBV antigen and may contribute to the pathogenesis of 
      nasopharyngeal carcinoma in cooperation with EBV.
FAU - Xia, Q
AU  - Xia Q
AD  - Qingdao Municipal Hospital, Qingdao 266011.
FAU - Meng, G
AU  - Meng G
FAU - Ai, Y
AU  - Ai Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (Antigens, Viral)
SB  - IM
MH  - Antigens, Viral/analysis
MH  - Burkitt Lymphoma/pathology/*virology
MH  - Cytopathogenic Effect, Viral
MH  - Herpesvirus 4, Human/immunology/*physiology
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - Lymphocytes/pathology
MH  - Nasopharyngeal Neoplasms/virology
MH  - Tumor Cells, Cultured
MH  - *Virus Replication
EDAT- 2001/11/23 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/23 10:00
PHST- 2001/11/23 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/23 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 1998 Aug;33(4):235-6.