PMID- 11718700
OWN - NLM
STAT- MEDLINE
DCOM- 20030103
LR  - 20190706
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 314
IP  - 1-2
DP  - 2001 Dec
TI  - Promoted expression of mast cell-specific proteases in IgE-dependent passive 
      cutaneous anaphylaxis responses.
PG  - 231-6
AB  - BACKGROUND: Various factors can influence the protease expression phenotype of 
      mast cells. METHODS: In an effort to understand the potential role of the mast 
      cell proteases in the IgE-dependent passive cutaneous anaphylaxis (PCA) responses 
      of murine tissues, we studied the changes of proteases expression. The 
      expressions of proteases were examined by Northern blotting and 
      immunohistochemistry. RESULTS: Promoted expression phenotypes of mouse mast cell 
      protease (mMCP)-4, and rat mast cell protease I were accompanied by initiation of 
      anti-dinitrophenyl (DNP) IgE-induced PCA responses, suggesting that the induction 
      of these proteases expression are associated with IgE-mediated anaphylaxis 
      responses. Elevated level of the L-histidine decarboxylase (HDC) mRNA expression 
      was also observed in the PCA tissues and the activated mast cells, compared with 
      that of the corresponding control tissue and cells, due to the activation of mast 
      cells. CONCLUSIONS: Promoted protease expression phenotype appears to be linked 
      with the induction of HDC expression.
FAU - Park, S J
AU  - Park SJ
AD  - Department of Oriental Pharmacy, College of Pharmacy, Korea Institute of Oriental 
      Pharmacy, Wonkwang University, Iksan, Chonbuk 570-749, South Korea.
FAU - Cho, S S
AU  - Cho SS
FAU - Oh, J M
AU  - Oh JM
FAU - Han, M K
AU  - Han MK
FAU - Song, Y S
AU  - Song YS
FAU - Bae, H R
AU  - Bae HR
FAU - Yoo, Y H
AU  - Yoo YH
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (DNA Probes)
RN  - 0 (RNA, Messenger)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.- (Endopeptidases)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - DNA Probes
MH  - Endopeptidases/*biosynthesis/genetics
MH  - Humans
MH  - Immunoglobulin E/*immunology
MH  - Immunohistochemistry
MH  - Mast Cells/*enzymology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Passive Cutaneous Anaphylaxis/immunology/*physiology
MH  - Phenotype
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Skin/cytology/enzymology
MH  - Tumor Cells, Cultured
EDAT- 2001/11/24 10:00
MHDA- 2003/01/04 04:00
CRDT- 2001/11/24 10:00
PHST- 2001/11/24 10:00 [pubmed]
PHST- 2003/01/04 04:00 [medline]
PHST- 2001/11/24 10:00 [entrez]
AID - S0009-8981(01)00706-9 [pii]
AID - 10.1016/s0009-8981(01)00706-9 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2001 Dec;314(1-2):231-6. doi: 10.1016/s0009-8981(01)00706-9.