PMID- 11718853
OWN - NLM
STAT- MEDLINE
DCOM- 20020110
LR  - 20190916
IS  - 0166-2236 (Print)
IS  - 0166-2236 (Linking)
VI  - 24
IP  - 12
DP  - 2001 Dec
TI  - BDNF as an anterophin; a novel neurotrophic relationship between brain neurons.
PG  - 683-4; discussion 684-5
AB  - Studies of the peripheral nervous system have led to the concept of 
      target-derived neurotrophic support. Neurotrophic factors such as nerve growth 
      factor are now known to act as retrograde trophic factors--retrophins--that are 
      produced in the target cells and released to presynaptic neurons. However, using 
      brain-derived neurotrophic factor (BDNF) tagged with green-fluorescent protein to 
      monitor the subcellular dynamics of BDNF in neurites, Tsumoto and colleagues have 
      provided persuasive visual evidence that BDNF can be released at the synapses of 
      brain neurons in an activity-dependent manner to act on postsynaptic neurons. 
      Accordingly, BDNF serves as an anterophin to regulate postsynaptic development 
      and plasticity in the central nervous system.
FAU - Nawa, H
AU  - Nawa H
AD  - Division of Molecular Neurobiology, Brain Research Institute, Niigata University, 
      951-8585 Japan. hnawa@bri.niigata-u.ac.jp
FAU - Takei, N
AU  - Takei N
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Trends Neurosci
JT  - Trends in neurosciences
JID - 7808616
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/*physiology
MH  - Synapses/*metabolism
RF  - 19
EDAT- 2001/11/24 10:00
MHDA- 2002/01/11 10:01
CRDT- 2001/11/24 10:00
PHST- 2001/11/24 10:00 [pubmed]
PHST- 2002/01/11 10:01 [medline]
PHST- 2001/11/24 10:00 [entrez]
AID - S0166-2236(00)01955-X [pii]
AID - 10.1016/s0166-2236(00)01955-x [doi]
PST - ppublish
SO  - Trends Neurosci. 2001 Dec;24(12):683-4; discussion 684-5. doi: 
      10.1016/s0166-2236(00)01955-x.