PMID- 11719089
OWN - NLM
STAT- MEDLINE
DCOM- 20020207
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 513
IP  - 1-2
DP  - 2002 Jan 15
TI  - Antiproliferative and cytotoxic effect of a novel organotin compound on mammalian 
      cells both in vitro and in vivo.
PG  - 49-59
AB  - Organotin compounds are organometallic compounds showing various toxicological 
      properties. Several organotin compounds also showed an antineoplastic effect. 
      However, their relative mutagenic potential is not well established. In this 
      study Et(2)SnCl(2).L [L=N-(2-pyridylmethylene)-4-toluidine] (OTC) has been 
      subjected to investigation for its cytotoxic effect in mouse bone marrow cells 
      (BMCs) and human peripheral blood lymphocyte cells (HPBLs). The Sn [bond] N bond 
      in OTC is 2.46A which is greater than 2.39A and therefore, a better formation of 
      tin-DNA complex can be expected. The present data indicate that OTC induced 
      significant delay in cell kinetics and sister chromatid exchanges (SCEs) in both 
      BMCs and HPBLs, whereas, induction of chromosome aberrations was found only in 
      HPBLs. The presence of buthionine sulfoximine (BSO) modulated cellular 
      sensitivity towards OTC in both cell systems. It may be inferred that the OTC 
      could bind on DNA more easily owing to its structural advantage and this may 
      explain the induction of DNA damage and the delay in cell proliferation. Since 
      the cytotoxic effect of OTC is more in glutathione depleted cells, the 
      concentration of OTC may be reduced to get an antitumour effect in GSH-depleted 
      cells and thus minimizes its toxic side effect.
FAU - Syng-ai, Christine
AU  - Syng-ai C
AD  - Genetics Laboratory, Department of Zoology, North-Eastern Hill University, 
      Shillong 793022, India.
FAU - Basu Baul, Tushar S
AU  - Basu Baul TS
FAU - Chatterjee, Anupam
AU  - Chatterjee A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Organotin Compounds)
RN  - 5072-26-4 (Buthionine Sulfoximine)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*toxicity
MH  - Buthionine Sulfoximine/pharmacology
MH  - Cell Division/drug effects
MH  - Chromosome Aberrations
MH  - DNA Damage
MH  - Glutathione/analysis
MH  - Humans
MH  - Male
MH  - Mice
MH  - Organotin Compounds/*toxicity
MH  - Sister Chromatid Exchange/drug effects
EDAT- 2001/11/24 10:00
MHDA- 2002/02/08 10:01
CRDT- 2001/11/24 10:00
PHST- 2001/11/24 10:00 [pubmed]
PHST- 2002/02/08 10:01 [medline]
PHST- 2001/11/24 10:00 [entrez]
AID - S1383571801002893 [pii]
AID - 10.1016/s1383-5718(01)00289-3 [doi]
PST - ppublish
SO  - Mutat Res. 2002 Jan 15;513(1-2):49-59. doi: 10.1016/s1383-5718(01)00289-3.