PMID- 11719268
OWN - NLM
STAT- MEDLINE
DCOM- 20020207
LR  - 20220331
IS  - 0361-9230 (Print)
IS  - 0361-9230 (Linking)
VI  - 56
IP  - 3-4
DP  - 2001 Oct-Nov 1
TI  - Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free 
      radical production in striatal neurons but does not prevent cell death.
PG  - 331-5
AB  - In hereditary Huntington's disease, a triplet repeat disease, there is extensive 
      loss of striatal neurons. It has been shown that brain-derived neurotrophic 
      factor (BDNF) protects striatal neurons against a variety of insults. We 
      confirmed that BDNF enhances survival and DARPP-32 expression in primary striatal 
      cultures derived from postnatal mice. Furthermore, BDNF inhibited intracellular 
      oxyradical stress triggered by dopamine, and partially blocked basal and 
      dopamine-induced apoptosis. Nevertheless, BDNF failed to rescue striatal neurons 
      from dopamine-induced cell death. Therefore, BDNF inhibits free radical and 
      apoptotic pathways in medium spiny neurons, but does so downstream from the point 
      of commitment to cell death.
FAU - Petersen A, A
AU  - Petersen A A
AD  - Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, 
      Lund, Sweden.
FAU - Larsen, K E
AU  - Larsen KE
FAU - Behr, G G
AU  - Behr GG
FAU - Romero, N
AU  - Romero N
FAU - Przedborski, S
AU  - Przedborski S
FAU - Brundin, P
AU  - Brundin P
FAU - Sulzer, D
AU  - Sulzer D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine and cAMP-Regulated Phosphoprotein 32)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Free Radicals)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Phosphoproteins)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Autophagy
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Corpus Striatum/*cytology
MH  - Dopamine/*pharmacology
MH  - Dopamine and cAMP-Regulated Phosphoprotein 32
MH  - Enzyme Inhibitors/pharmacology
MH  - Free Radicals/metabolism
MH  - Huntington Disease/genetics/pathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Nerve Tissue Proteins
MH  - Neurons/cytology/*drug effects/metabolism
MH  - Oxidative Stress/physiology
MH  - Phosphoproteins/pharmacology
MH  - Trinucleotide Repeats
EDAT- 2001/11/24 10:00
MHDA- 2002/02/08 10:01
CRDT- 2001/11/24 10:00
PHST- 2001/11/24 10:00 [pubmed]
PHST- 2002/02/08 10:01 [medline]
PHST- 2001/11/24 10:00 [entrez]
AID - S0361923001005809 [pii]
AID - 10.1016/s0361-9230(01)00580-9 [doi]
PST - ppublish
SO  - Brain Res Bull. 2001 Oct-Nov 1;56(3-4):331-5. doi: 10.1016/s0361-9230(01)00580-9.