PMID- 11719392
OWN - NLM
STAT- MEDLINE
DCOM- 20011220
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 98
IP  - 12
DP  - 2001 Dec 1
TI  - Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with 
      leukemic mantle cell lymphoma.
PG  - 3479-82
AB  - Patients with mantle cell lymphoma (MCL) may present with either nodal or 
      leukemic disease. The molecular determinants underlying this different biologic 
      behavior are not known. This study compared the pattern of genetic abnormalities 
      in patients with nodal and leukemic phases of MCL using comparative genomic 
      hybridization (CGH) and fluorescence in situ hybridization (FISH) for specific 
      gene loci. Although both leukemic and nodal MCL showed similar genomic patterns 
      of losses (involving 6q, 11q22-q23, 13q14, and 17p13) and gains (affecting 3q and 
      8q), genomic loss of chromosome 8p occurred more frequently in patients with 
      leukemic disease (79% versus 11%, P <.001). Subsequent CGH analysis confirmed the 
      genomic loss of 8p21-p23 in 6 of 8 MCL cell lines. Interestingly, MYC gene 
      amplification was restricted to cases with 8p deletion. These data indicate the 
      presence of a novel tumor suppressor gene locus on 8p, whose deletion may be 
      associated with leukemic dissemination and poor prognosis in patients with MCL.
FAU - Martinez-Climent, J A
AU  - Martinez-Climent JA
AD  - Department of Hematology and Medical Oncology, Hospital Clinico, University of 
      Valencia, Spain. martinez_jos@gva.es
FAU - Vizcarra, E
AU  - Vizcarra E
FAU - Sanchez, D
AU  - Sanchez D
FAU - Blesa, D
AU  - Blesa D
FAU - Marugan, I
AU  - Marugan I
FAU - Benet, I
AU  - Benet I
FAU - Sole, F
AU  - Sole F
FAU - Rubio-Moscardo, F
AU  - Rubio-Moscardo F
FAU - Terol, M J
AU  - Terol MJ
FAU - Climent, J
AU  - Climent J
FAU - Sarsotti, E
AU  - Sarsotti E
FAU - Tormo, M
AU  - Tormo M
FAU - Andreu, E
AU  - Andreu E
FAU - Salido, M
AU  - Salido M
FAU - Ruiz, M A
AU  - Ruiz MA
FAU - Prosper, F
AU  - Prosper F
FAU - Siebert, R
AU  - Siebert R
FAU - Dyer, M J
AU  - Dyer MJ
FAU - Garcia-Conde, J
AU  - Garcia-Conde J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
SB  - IM
MH  - *Chromosomes, Human, Pair 8
MH  - Gene Amplification
MH  - *Gene Deletion
MH  - *Genes, Tumor Suppressor
MH  - Genes, myc/genetics
MH  - Humans
MH  - In Situ Hybridization
MH  - Lymphoma, Mantle-Cell/*genetics/*pathology
MH  - Nucleic Acid Hybridization
MH  - Prognosis
EDAT- 2001/11/24 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/24 10:00
PHST- 2001/11/24 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/24 10:00 [entrez]
AID - S0006-4971(20)56805-5 [pii]
AID - 10.1182/blood.v98.12.3479 [doi]
PST - ppublish
SO  - Blood. 2001 Dec 1;98(12):3479-82. doi: 10.1182/blood.v98.12.3479.