PMID- 11721090
OWN - NLM
STAT- MEDLINE
DCOM- 20020208
LR  - 20220408
IS  - 1422-4933 (Print)
IS  - 1422-4933 (Linking)
VI  - 10
IP  - 6
DP  - 2001 Nov-Dec
TI  - A run for a membrane vitamin D receptor.
PG  - 341-9
AB  - 1,25-Dihydroxyvitamin D(3) is the hormonally active form of vitamin D(3). Its 
      involvement in regulation of calcium and phosphate homeostasis as well as in 
      differentiation and regulation of the immune system is well documented. Extensive 
      data indicate that there are two mechanisms of the molecular mode-of-action of 
      1,25-dihydroxyvitamin D(3). One involves the activation of nuclear vitamin D 
      receptor (nVDR) and transcriptional regulation of many vitamin D-responsive 
      genes. The other involves activation of nongenomic signal transduction pathways 
      in target cells. This second mechanism is likely to engage a membrane vitamin D 
      receptor (mVDR). Recently discovered 64.5 kDa protein from chick epithelium, 
      which specifically binds 1,25-dihydroxyvitamin D(3) and is responsible for some 
      rapid cellular actions of 1,25-dihydroxyvitamin D(3) is a candidate for mVDR. 
      This article provides a brief description of a search for a putative mVDR that 
      lasted for over a decade.
CI  - Copyright 2001 S. Karger AG, Basel
FAU - Marcinkowska, E
AU  - Marcinkowska E
AD  - Department of Reproductive Immunology, Ludwik Hirszfeld Institute of Immunology 
      and Experimental Therapy, Polish Academy of Sciences, Weigl st. 12, 53-114 
      Wroclaw, Poland. marcinko@immuno.iitd.pan.wroc.pl
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Biol Signals Recept
JT  - Biological signals and receptors
JID - 9808792
RN  - 0 (Receptors, Calcitriol)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Animals
MH  - Calcitriol/pharmacology
MH  - Cell Membrane/drug effects/metabolism
MH  - Cell Nucleus/drug effects/metabolism
MH  - Chickens
MH  - Humans
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Receptors, Calcitriol/*metabolism
MH  - Signal Transduction/drug effects
RF  - 54
EDAT- 2001/11/27 10:00
MHDA- 2002/02/09 10:01
CRDT- 2001/11/27 10:00
PHST- 2001/11/27 10:00 [pubmed]
PHST- 2002/02/09 10:01 [medline]
PHST- 2001/11/27 10:00 [entrez]
AID - bsi10341 [pii]
AID - 10.1159/000046902 [doi]
PST - ppublish
SO  - Biol Signals Recept. 2001 Nov-Dec;10(6):341-9. doi: 10.1159/000046902.