PMID- 11721367
OWN - NLM
STAT- MEDLINE
DCOM- 20011211
LR  - 20071115
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 20
IP  - 12
DP  - 1999 Dec
TI  - [Detection of aberrant chromosomes in acute lymphoblastic leukemia by 
      fluorescence in situ hybridization].
PG  - 640-2
AB  - OBJECTIVE: To investigate the value of fluorescence in situ hybridization (FISH) 
      in detecting aberrant chromosomes in acute lymphoblastic leukemias. METHODS: 
      Conventional banding techniques and FISH were used to detect trisomy 17, 18 and 
      21 in 38 patients with acute lymphoblastic leukemia. Lymphoid DNA probes specific 
      for chromosomes no. 17, 18 and 21 were used for FISH. RESULTS: Out of the 38 
      patients, 18 had + 17, 22 + 18 and 23 + 21. The number of trisomy cells ranged 
      from 7% to 80%. Ten normal bone marrow samples were hybridized with the 
      chromosomes 17, 18 and 21 probes. CONCLUSION: FISH is more sensitive than 
      conventional cytogenetic analysis and allows systematic study on large cohort of 
      patients without the need of metaphase preparations.
FAU - Yang, K
AU  - Yang K
AD  - Beijing Army General Hospital of PLA, Beijing 100700.
FAU - Huang, L
AU  - Huang L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - *Chromosome Aberrations
MH  - Chromosome Banding
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Chromosomes, Human, Pair 18/genetics
MH  - Chromosomes, Human, Pair 21/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Trisomy
MH  - Tumor Cells, Cultured
EDAT- 2001/11/28 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/11/28 10:00
PHST- 2001/11/28 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/11/28 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 1999 Dec;20(12):640-2.