PMID- 1172158 OWN - NLM STAT- MEDLINE DCOM- 19751204 LR - 20061115 IS - 0300-8630 (Print) IS - 0300-8630 (Linking) VI - 187 IP - 4 DP - 1975 Jul TI - [Genetic studies in hypoplastic left heart syndrome (author's transl)]. PG - 342-5 AB - The families of the 18 patients with hypoplastic left heart syndrome (HLH), who died in the Universitatskinderklinik Erlangen between 1967 and January 1974, have been investigated. There was no consanguinity of the parents. Only one sib has died of a cardiac failure which possibly could have been HLH. Therefore it could be excluded that HLH is an autosomal-recessive disorder. The overall incidence of cardiac failure in the sibs of patients was 3. Most of the patients with HLH have been born in June-August and December-January. Environmental factors seem to be of importance in the genesis of HLH. Our results suggest multifactorial inheritance of the hypoplastic left heart syndrome. FAU - Grosse, K P AU - Grosse KP FAU - Reither, M AU - Reither M FAU - Falge, R AU - Falge R LA - ger PT - English Abstract PT - Journal Article TT - Beitrag zur Genetik des Syndroms des hypoplastischen Linksherzens. PL - Germany TA - Klin Padiatr JT - Klinische Padiatrie JID - 0326144 SB - IM MH - Abnormalities, Multiple/genetics MH - Age Factors MH - Female MH - Heart Defects, Congenital/*genetics MH - Humans MH - Infant MH - Male MH - Pregnancy MH - Pregnancy Complications MH - Seasons MH - Sex Factors MH - Syndrome EDAT- 1975/07/01 00:00 MHDA- 1975/07/01 00:01 CRDT- 1975/07/01 00:00 PHST- 1975/07/01 00:00 [pubmed] PHST- 1975/07/01 00:01 [medline] PHST- 1975/07/01 00:00 [entrez] PST - ppublish SO - Klin Padiatr. 1975 Jul;187(4):342-5.