PMID- 11721619
OWN - NLM
STAT- MEDLINE
DCOM- 20020418
LR  - 20181113
IS  - 1073-6085 (Print)
IS  - 1073-6085 (Linking)
VI  - 19
IP  - 3
DP  - 2001 Nov
TI  - Hot topics in adeno-associated virus as a gene transfer vector.
PG  - 229-37
AB  - Adeno-associated virus (AAV) is a promising viral vector in treating many kinds 
      of hereditary diseases. The broad host range, low level of immune response, and 
      longevity of gene expression observed with this vector have enabled the 
      initiation of a number of clinical trials using this gene delivery system. 
      Another potential benefit of AAV vectors is their ability to integrate 
      site-specifically in the presence of Rep proteins. However, this virus is not 
      well characterized. To obtain high level, persistent expression of the foreign 
      gene, some problems should be solved. In this article, we will describe the 
      advances in some fields of recombinant AAV technology that overcome certain 
      limitations of the vector as a gene delivery system, such as the transduction 
      efficiency, the production, the package capacity, and elimination of immune 
      responses, as well as the applications involving these recombinant vectors for 
      the treatment of some diseases.
FAU - Zhao, N
AU  - Zhao N
AD  - National Laboratory of Medical Molecular Biology, Institute of Basic Medical 
      Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 
      Beijing 100005, P. R. China.
FAU - Liu, D P
AU  - Liu DP
FAU - Liang, C C
AU  - Liang CC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Mol Biotechnol
JT  - Molecular biotechnology
JID - 9423533
SB  - IM
MH  - Dependovirus/*genetics
MH  - *Gene Transfer Techniques
MH  - *Genetic Vectors
MH  - Transfection
RF  - 58
EDAT- 2001/11/28 10:00
MHDA- 2002/04/19 10:01
CRDT- 2001/11/28 10:00
PHST- 2001/11/28 10:00 [pubmed]
PHST- 2002/04/19 10:01 [medline]
PHST- 2001/11/28 10:00 [entrez]
AID - MB:19:3:229 [pii]
AID - 10.1385/MB:19:3:229 [doi]
PST - ppublish
SO  - Mol Biotechnol. 2001 Nov;19(3):229-37. doi: 10.1385/MB:19:3:229.