PMID- 11722992 OWN - NLM STAT- MEDLINE DCOM- 20020717 LR - 20191105 IS - 1520-4391 (Print) IS - 1520-4383 (Linking) DP - 2001 TI - Anticoagulation therapy. PG - 339-57 AB - Despite refinements and standardization in the use of anticoagulants, many problems remain for clinicians. Dr. Crowther describes appropriate starting and maintenance doses of warfarin, factors accounting for inter- and intra-observer variability and importantly, the management of the over-anticoagulated patients and bleeding patients. Dr. White compares unfractionated heparin (UFH) and low molecular weight heparin (LMWH) and addresses whether there truly are differences in the efficacy and safety of different LMWH's for both arterial and venous indications. Dr. Ortel discusses the management of the problem patient who requires anticoagulants, the management of heparin-induced thrombocytopenia, the pregnant patient, the obese patient, patients who have renal insufficiency and/or liver disease, patients with malignant disease, and other challenging patient populations. FAU - Ginsberg, J A AU - Ginsberg JA AD - Department of Hematology, St.Joseph's Hospital, Hamilton, Canada. FAU - Crowther, M A AU - Crowther MA FAU - White, R H AU - White RH FAU - Ortel, T L AU - Ortel TL LA - eng PT - Journal Article PT - Review PL - United States TA - Hematology Am Soc Hematol Educ Program JT - Hematology. American Society of Hematology. Education Program JID - 100890099 RN - 0 (Anticoagulants) RN - 0 (Heparin, Low-Molecular-Weight) RN - 5Q7ZVV76EI (Warfarin) SB - IM MH - Anticoagulants/administration & dosage/adverse effects/*therapeutic use MH - Female MH - Heparin, Low-Molecular-Weight/administration & dosage/adverse effects/standards MH - Humans MH - Male MH - Pregnancy MH - Pregnancy Complications, Hematologic/diagnosis/drug therapy/prevention & control MH - Thrombocytopenia/chemically induced MH - Warfarin/administration & dosage/adverse effects/standards RF - 132 EDAT- 2001/11/28 10:00 MHDA- 2002/07/18 10:01 CRDT- 2001/11/28 10:00 PHST- 2001/11/28 10:00 [pubmed] PHST- 2002/07/18 10:01 [medline] PHST- 2001/11/28 10:00 [entrez] AID - 10.1182/asheducation-2001.1.339 [doi] PST - ppublish SO - Hematology Am Soc Hematol Educ Program. 2001:339-57. doi: 10.1182/asheducation-2001.1.339.