PMID- 11724418
OWN - NLM
STAT- MEDLINE
DCOM- 20020509
LR  - 20190816
IS  - 0012-186X (Print)
IS  - 0012-186X (Linking)
VI  - 44 Suppl 3
DP  - 2001 Oct
TI  - Correlations between the incidence of childhood-onset type I diabetes in Europe 
      and HLA genotypes.
PG  - B51-9
AB  - There are large variations in the incidence of Type I (insulin-dependent) 
      diabetes mellitus within Europe, ranging from 3.2 cases per 100,000 person-years 
      in the Republic of Macedonia to more than 40 new cases per 100,000 person-years 
      in Finland. This variation could be caused by differences in the distribution of 
      genetic susceptibility markers, by differences in the distribution of 
      environmental disease determinants or by a combination of both. To assess how 
      much genes contribute to this variation, we correlated the level of incidence of 
      Type I diabetes with the prevalence in the general population of genetic 
      susceptibility and protective markers encoded by the human leukocyte antigen 
      (HLA)-DQ loci. Positive association was found for the combined group of genotypes 
      associated with Type I diabetes risk (p < 0.001). The whole positive effect was, 
      however, accounted for by the HLA-DQ2/ DQ8 
      (DQA1*0501-DQB1*0201/DQA1*0301-DQB1*0302) and HLA-DQ4/DQ8 
      (DQA1*0401-DQB1*0402/DQA*0301-DQB1*0302) genotypes (p < 0.001 and p < 0.004, 
      respectively). No correlation was found between incidence of Type I diabetes and 
      population prevalence of genotypes not encoding for aspartate on position 57 on 
      the HLA-DQbeta chain. It was not possible to detect any negative correlation 
      between Type I diabetes incidence and the prevalence of HLA-genotypes conferring 
      protection against Type I diabetes in a population (HLA-DQA1*0102-DQB1*0602/X). 
      The results suggest that a substantial part of the transnational variation in the 
      incidence of childhood-onset Type I diabetes in Europe is explained by variations 
      between populations in the distribution of particular DQ genotypes which confer a 
      high risk of Type I diabetes in the general population.
FAU - Ronningen, K S
AU  - Ronningen KS
AD  - Department of Population Health Sciences, National Institute of Public Health, 
      Oslo, Norway.
FAU - Keiding, N
AU  - Keiding N
FAU - Green, A
AU  - Green A
CN  - EURODIAB ACE Study Group. Europe and Diabetes
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Diabetologia
JT  - Diabetologia
JID - 0006777
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Age of Onset
MH  - Child
MH  - Diabetes Mellitus, Type 1/*epidemiology/genetics/*immunology
MH  - Europe/epidemiology
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - Humans
MH  - Incidence
MH  - *Major Histocompatibility Complex
MH  - Prevalence
MH  - Regression Analysis
EDAT- 2001/11/29 10:00
MHDA- 2002/05/10 10:01
CRDT- 2001/11/29 10:00
PHST- 2001/11/29 10:00 [pubmed]
PHST- 2002/05/10 10:01 [medline]
PHST- 2001/11/29 10:00 [entrez]
AID - 10.1007/pl00002955 [doi]
PST - ppublish
SO  - Diabetologia. 2001 Oct;44 Suppl 3:B51-9. doi: 10.1007/pl00002955.