PMID- 11725133
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1423-0127 (Electronic)
IS  - 1021-7770 (Linking)
VI  - 4
IP  - 1
DP  - 1997 Jan-Feb
TI  - HTLV-I Tax and Cytokeratin: Tax-Expressing Cells Show Morphological Changes in 
      Keratin-Containing Cytoskeletal Networks.
PG  - 47-53
AB  - Human T cell leukemia virus type I (HTLV-I) has been linked to the development of 
      an aggressive lymphoproliferative disorder (adult T cell leukemia), a chronic 
      neurodegenerative presentation (HTLV-I-associated myelopathy/tropical spastic 
      paraparesis) and numerous less well-defined inflammatory conditions. The viral 
      regulatory protein Tax has been implicated in cellular transformation events 
      leading to the onset of adult T cell leukemia. Details on the stepwise processes 
      through which Tax induces morphological changes in cells are poorly understood. 
      We show here that Tax can bind to a class of intermediate filaments, the 
      cytokeratins (Ker). Tax interacts with the 1B helical coil of keratin 8, a domain 
      critical for higher-order intermediate filament matrix formation. Expression of 
      Tax in epithelial cells visibly altered the structural pattern of the Ker 
      network. In a T lymphocyte cell line, induction of Tax expression resulted in 
      increased cellular adherence/invasion of Matrigel filters. We propose that one 
      aspect of Tax function is the induction of morphological changes in cellular 
      cytoskeletal structures. This finding for Tax-expressing cells might be one 
      factor contributing directly to the pathogenesis of HTLV-I disease(s). Copyright 
      1997 S. Karger AG, Basel
FAU - Trihn, D
AU  - Trihn D
AD  - Molecular Virology Section, Laboratory of Molecular Microbiology, National 
      Institute of Allergy and Infectious Diseases, Bethesda, Md., USA.
FAU - Jeang, K-T
AU  - Jeang KT
FAU - Semmes, OJ
AU  - Semmes OJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Biomed Sci
JT  - Journal of biomedical science
JID - 9421567
EDAT- 1997/01/01 00:00
MHDA- 2001/11/29 10:00
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 2001/11/29 10:00 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - jbs04047 [pii]
AID - 10.1007/BF02255593 [doi]
PST - ppublish
SO  - J Biomed Sci. 1997 Jan-Feb;4(1):47-53. doi: 10.1007/BF02255593.