PMID- 11725134
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1423-0127 (Electronic)
IS  - 1021-7770 (Linking)
VI  - 4
IP  - 1
DP  - 1997 Jan-Feb
TI  - Detection of HTLV-I in Peripheral Blood Lymphocytes from Patients with Chronic 
      HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis and Asymptomatic 
      Carriers by PCR-in situ Hybridization.
PG  - 54-60
AB  - Less than 5% of people infected with human T-lymphotropic virus type I (HTLV-I) 
      develop HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a 
      chronic progressive neurologic disease. A number of factors have been implicated 
      in the development of HAM/TSP including heterogeneity of viral sequences, 
      host-genetic background, viral-specific cellular immune responses and viral load. 
      This study examined the presence of HTLV-1 tax DNA in peripheral blood 
      lymphocytes (PBL) from 2 chronic HAM/TSP patients and 2 asymptomatic HTLV-I 
      carriers by using PCR-in situ hybridization (PCR-ISH) for the in situ presence of 
      proviral HTLV-I tax DNA. By this technique, rare PBL from these HTLV-I-infected 
      individuals contained HTLV-I DNA. PCR-ISH did not detect any difference in the 
      number of infected cells between HAM/TSP patients and asymptomatic carriers. 
      Copyright 1997 S. Karger AG, Basel
FAU - Walter, MJ
AU  - Walter MJ
AD  - Neuroimmunology Branch/NINDS, National Institutes of Health, Bethesda, Md., USA.
FAU - Lehky, TJ
AU  - Lehky TJ
FAU - Levin, MC
AU  - Levin MC
FAU - Fox, CH
AU  - Fox CH
FAU - Jacobson, S
AU  - Jacobson S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Biomed Sci
JT  - Journal of biomedical science
JID - 9421567
EDAT- 1997/01/01 00:00
MHDA- 2001/11/29 10:00
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 2001/11/29 10:00 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - jbs04054 [pii]
AID - 10.1007/BF02255594 [doi]
PST - ppublish
SO  - J Biomed Sci. 1997 Jan-Feb;4(1):54-60. doi: 10.1007/BF02255594.