PMID- 11726530
OWN - NLM
STAT- MEDLINE
DCOM- 20020115
LR  - 20120215
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 15
IP  - 14
DP  - 2001 Dec
TI  - Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through 
      toll-like receptor 4-derived signaling pathways.
PG  - 2556-64
AB  - Genetic evidence that Toll-like receptor 4 (Tlr4) is the lipopolysaccharide (LPS) 
      receptor and biochemical evidence that Tlr4 confers LPS responsiveness as 
      determined by activation of NF-kappaB and expression of inducible cyclooxygenase 
      2 have been demonstrated. Saturated fatty acids (SFAs) acylated in lipid A moiety 
      of LPS are essential for biological activities of LPS. It is now demonstrated 
      that SFAs, but not unsaturated fatty acids (UFAs), induce NF-kappaB activation 
      and expression of COX-2 and other inflammatory markers in macrophages. UFAs 
      inhibit COX-2 expression induced by SFAs and LPS. Additional evidence suggests 
      that both SFA-induced COX-2 expression and its inhibition by UFAs are mediated 
      through a common signaling pathway derived from Tlr4. These results represent a 
      novel mechanism by which fatty acids modulate signaling pathways and target gene 
      expression. Whether fatty acids also modulate signaling pathways and target gene 
      expression derived from the activation of other Tlrs remains to be 
      determined.-Hwang, D. Modulation of the expression of cyclooxygenase 2 by fatty 
      acids mediated through Toll-like receptor 4-derived signaling pathways.
FAU - Hwang, D
AU  - Hwang D
AD  - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, 
      Louisiana 70808, USA. hwangdh@pbrc.edu
LA  - eng
GR  - CA-75613/CA/NCI NIH HHS/United States
GR  - DK-41868/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Drosophila Proteins)
RN  - 0 (Fatty Acids)
RN  - 0 (Isoenzymes)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - EC 1.14.99.1 (PTGS2 protein, human)
RN  - EC 1.14.99.1 (Prostaglandin-Endoperoxide Synthases)
SB  - IM
MH  - Animals
MH  - Cyclooxygenase 2
MH  - *Drosophila Proteins
MH  - Fatty Acids/*pharmacology
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - Humans
MH  - Isoenzymes/*drug effects/genetics/metabolism
MH  - Membrane Glycoproteins/*physiology
MH  - Membrane Proteins
MH  - Prostaglandin-Endoperoxide Synthases/*drug effects/genetics/metabolism
MH  - Receptors, Cell Surface/*physiology
MH  - Signal Transduction/*physiology
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptors
RF  - 74
EDAT- 2001/12/01 10:00
MHDA- 2002/01/16 10:01
CRDT- 2001/12/01 10:00
PHST- 2001/12/01 10:00 [pubmed]
PHST- 2002/01/16 10:01 [medline]
PHST- 2001/12/01 10:00 [entrez]
AID - 15/14/2556 [pii]
AID - 10.1096/fj.01-0432com [doi]
PST - ppublish
SO  - FASEB J. 2001 Dec;15(14):2556-64. doi: 10.1096/fj.01-0432com.