PMID- 11726795
OWN - NLM
STAT- MEDLINE
DCOM- 20020111
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 12
IP  - 17
DP  - 2001 Dec 4
TI  - 17beta-Estradiol increases, aging decreases, c-Fos expression in the rat 
      accessory olfactory bulb.
PG  - 3787-90
AB  - In the present paper we investigated the c-Fos immunoreactivity in the accessory 
      olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as 
      the effect of 17beta-estradiol on the expression of this immediate early gene. 
      Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen 
      treatment caused an increase in the number of neurons expressing c-Fos in the 
      AOB. The results indicate that both aging and estrogen have roles in the ability 
      of neurons to co-ordinate genetic activity. Our observations may explain the 
      decrease in age-related changes of brain plasticity, and provide data for the 
      understanding of hormonally regulated neuronal plasticity.
FAU - Balog, J A
AU  - Balog JA
AD  - Molecular Neurobiology Laboratory, Institute of Biophysics, Biological Research 
      Center, 6701 Szeged, P.O. Box 521, Hungary.
FAU - Kurunczi, A
AU  - Kurunczi A
FAU - Parducz A, A
AU  - Parducz A A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Sex Attractants)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Aging/drug effects/*physiology
MH  - Animals
MH  - Cell Differentiation/drug effects/physiology
MH  - Down-Regulation/drug effects/physiology
MH  - Estradiol/*metabolism/pharmacology
MH  - Female
MH  - Gene Expression Regulation, Developmental/drug effects/physiology
MH  - Immunohistochemistry
MH  - Male
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Neurons/cytology/drug effects/*metabolism
MH  - Olfactory Bulb/drug effects/*growth & development/metabolism
MH  - Proto-Oncogene Proteins c-fos/drug effects/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reproduction/drug effects/physiology
MH  - Sex Attractants/metabolism
MH  - Sex Characteristics
MH  - Synapses/drug effects/*metabolism
MH  - Up-Regulation/drug effects/physiology
EDAT- 2001/12/01 10:00
MHDA- 2002/01/12 10:01
CRDT- 2001/12/01 10:00
PHST- 2001/12/01 10:00 [pubmed]
PHST- 2002/01/12 10:01 [medline]
PHST- 2001/12/01 10:00 [entrez]
AID - 10.1097/00001756-200112040-00037 [doi]
PST - ppublish
SO  - Neuroreport. 2001 Dec 4;12(17):3787-90. doi: 10.1097/00001756-200112040-00037.