PMID- 11726931
OWN - NLM
STAT- MEDLINE
DCOM- 20011220
LR  - 20240109
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 29
IP  - 4
DP  - 2001 Dec
TI  - Natural variation in light sensitivity of Arabidopsis.
PG  - 441-6
AB  - Because plants depend on light for growth, their development and physiology must 
      suit the particular light environment. Plants native to different environments 
      show heritable, apparently adaptive, changes in their response to light. As a 
      first step in unraveling the genetic and molecular basis of these naturally 
      occurring differences, we have characterized intraspecific variation in a 
      light-dependent developmental process-seedling emergence. We examined 141 
      Arabidopsis thaliana accessions for their response to four light conditions, two 
      hormone conditions and darkness. There was significant variation in all 
      conditions, confirming that Arabidopsis is a rich source of natural genetic 
      diversity. Hierarchical clustering revealed that some accessions had response 
      patterns similar to known photoreceptor mutants, suggesting changes in specific 
      signaling pathways. We found that the unusual far-red response of the Lm-2 
      accession is due to a single amino-acid change in the phytochrome A (PHYA) 
      protein. This change stabilizes the light-labile PHYA protein in light and causes 
      a 100-fold shift in the threshold for far-red light sensitivity. Purified 
      recombinant Lm-2 PHYA also shows subtle photochemical differences and has a 
      reduced capacity for autophosphorylation. These biochemical changes contrast with 
      previously characterized natural alleles in loci controlling plant development, 
      which result in altered gene expression or loss of gene function.
FAU - Maloof, J N
AU  - Maloof JN
AD  - Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 N 
      Torrey Pines Road, La Jolla, California 92037, USA.
FAU - Borevitz, J O
AU  - Borevitz JO
FAU - Dabi, T
AU  - Dabi T
FAU - Lutes, J
AU  - Lutes J
FAU - Nehring, R B
AU  - Nehring RB
FAU - Redfern, J L
AU  - Redfern JL
FAU - Trainer, G T
AU  - Trainer GT
FAU - Wilson, J M
AU  - Wilson JM
FAU - Asami, T
AU  - Asami T
FAU - Berry, C C
AU  - Berry CC
FAU - Weigel, D
AU  - Weigel D
FAU - Chory, J
AU  - Chory J
LA  - eng
GR  - GM08666/GM/NIGMS NIH HHS/United States
GR  - GM52413/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
SB  - IM
CIN - Nat Genet. 2001 Dec;29(4):357-8. PMID: 11726915
MH  - Arabidopsis/physiology/*radiation effects
MH  - *Light
MH  - Plants, Genetically Modified
EDAT- 2001/12/01 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/12/01 10:00
PHST- 2001/12/01 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/12/01 10:00 [entrez]
AID - ng777 [pii]
AID - 10.1038/ng777 [doi]
PST - ppublish
SO  - Nat Genet. 2001 Dec;29(4):441-6. doi: 10.1038/ng777.