PMID- 11727136
OWN - NLM
STAT- MEDLINE
DCOM- 20020328
LR  - 20131121
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 15
IP  - 11
DP  - 2001 Nov
TI  - Histologic evaluation of fetal brains following maternal pneumoperitoneum.
PG  - 1294-8
AB  - BACKGROUND: The purpose of this study was to determine if maternal 
      pneumoperitoneum with carbon dioxide (CO2) produces evidence of central nervous 
      system (CNS) injury in preterm fetal guinea pigs. METHODS: Thirty pregnant guinea 
      pigs at gestational day (GD) 45 were assigned at random to one of three treatment 
      groups: anesthesia only, CO2 pneumoperitoneum (5 mmHg), or laparotomy. Dams were 
      killed 3 or 5 days postprocedure and fetal brains (83 total) harvested and fixed 
      for subsequent histopathologic evaluation. For comparative purposes, histologic 
      features of fetal guinea pig brain injury were defined from examination of fetal 
      brains harvested from an additional dam that underwent laparotomy with 20 min of 
      uterine arterial occlusion. RESULTS: Carbon dioxide pneumoperitoneum did not 
      increase maternal/fetal morbidity. No evidence of brain injury was found in 
      fetuses from any of the treatment groups. CONCLUSION: Carbon dioxide 
      pneumoperitoneum at 5 mmHg for 40 min in the pregnant guinea pig does not produce 
      evidence of fetal brain injury.
FAU - Garcia-Oria, M
AU  - Garcia-Oria M
AD  - Department of Surgery, Duke University Medical Center, Endosurgery Research 
      Laboratory, Durham, NC, 27710, USA.
FAU - Ali, A
AU  - Ali A
FAU - Reynolds, J D
AU  - Reynolds JD
FAU - Clary, E
AU  - Clary E
FAU - Gandsas, A
AU  - Gandsas A
FAU - Cummings, T
AU  - Cummings T
FAU - McMahon, R L
AU  - McMahon RL
FAU - Bruch, S
AU  - Bruch S
FAU - Fina, M
AU  - Fina M
FAU - Ko, A
AU  - Ko A
FAU - Eubanks, S
AU  - Eubanks S
LA  - eng
PT  - Journal Article
DEP - 20010904
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Animals
MH  - Brain/*embryology/*pathology
MH  - Carbon Dioxide
MH  - Female
MH  - Guinea Pigs
MH  - Hemodynamics
MH  - Laparoscopy
MH  - Laparotomy
MH  - Pneumoperitoneum, Artificial/*adverse effects
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
EDAT- 2001/12/01 10:00
MHDA- 2002/03/29 10:01
CRDT- 2001/12/01 10:00
PHST- 2000/06/14 00:00 [received]
PHST- 2000/11/06 00:00 [accepted]
PHST- 2001/12/01 10:00 [pubmed]
PHST- 2002/03/29 10:01 [medline]
PHST- 2001/12/01 10:00 [entrez]
AID - 10.1007/s004640080040 [doi]
PST - ppublish
SO  - Surg Endosc. 2001 Nov;15(11):1294-8. doi: 10.1007/s004640080040. Epub 2001 Sep 4.