PMID- 11728201
OWN - NLM
STAT- MEDLINE
DCOM- 20020129
LR  - 20190930
IS  - 1083-3668 (Print)
IS  - 1083-3668 (Linking)
VI  - 6
IP  - 4
DP  - 2001 Oct
TI  - Surgical adhesives for laser-assisted wound closure.
PG  - 427-31
AB  - Solid protein solder-doped polymer membranes were developed for laser-assisted 
      tissue repair. Biodegradable polymer membranes of controlled porosity were 
      fabricated with poly(L-lactic-co-glycolic acid) (PLGA), poly(ethylene glycol) 
      (PEG), and salt particles, using a solvent-casting and particulate-leaching 
      technique. The membranes provided a porous scaffold that readily absorbed the 
      traditional protein solder composed of serum albumin, indocyanine green dye, and 
      de-ionized water. In vitro investigations were conducted to assess the influence 
      of various processing parameters on the strength of tissue repairs formed using 
      the new membranes. These parameters included PLGA copolymer and PLGA/PEG blend 
      ratios, membrane pore size, initial albumin weight fraction, and laser irradiance 
      used to denature the solder. Altering the PLGA copolymer ratio had little effect 
      on repair strength, however such variations are known to influence the 
      degradation rate of the membranes. The repair strength increased with increased 
      membrane pore size and bovine serum albumin concentration. The addition of PEG 
      during the membrane casting stage increased the flexibility of the membranes but 
      not necessarily the repair strength. Typically, the repair strength increased 
      with increasing irradiance from 12 to 18 W/cm(2). The new solder-doped polymer 
      membranes provided all of the benefits associated with solid protein solders 
      including high repair strength and improved edge coaptation. In addition, the 
      flexible, moldable nature of the new membranes offers the capability of tailoring 
      the membranes to a wide range of clinically relevant geometries.
FAU - Hodges, D E
AU  - Hodges DE
AD  - Biomedical Engineering Laser Laboratory, The University of Texas at Austin, 
      Austin, TX 78712, USA. diane.hodges@motorola.com
FAU - McNally, K M
AU  - McNally KM
FAU - Welch, A J
AU  - Welch AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
RN  - 0 (Biocompatible Materials)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Tissue Adhesives)
RN  - 0 (poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 34346-01-5 (Polyglactin 910)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - IX6J1063HV (Indocyanine Green)
SB  - IM
MH  - Animals
MH  - Aorta, Thoracic/*surgery
MH  - Biocompatible Materials/*therapeutic use
MH  - Cattle
MH  - Fluorescent Dyes
MH  - Indocyanine Green
MH  - Laser Therapy/*methods
MH  - Polyethylene Glycols/*therapeutic use
MH  - Polyglactin 910/*therapeutic use
MH  - Porosity
MH  - Serum Albumin, Bovine/therapeutic use
MH  - Tissue Adhesives/*therapeutic use
MH  - *Wound Healing
EDAT- 2001/12/01 10:00
MHDA- 2002/01/30 10:01
CRDT- 2001/12/01 10:00
PHST- 2000/06/29 00:00 [received]
PHST- 2001/04/05 00:00 [revised]
PHST- 2001/05/03 00:00 [accepted]
PHST- 2001/12/01 10:00 [pubmed]
PHST- 2002/01/30 10:01 [medline]
PHST- 2001/12/01 10:00 [entrez]
AID - 10.1117/1.1412436 [doi]
PST - ppublish
SO  - J Biomed Opt. 2001 Oct;6(4):427-31. doi: 10.1117/1.1412436.