PMID- 11731155
OWN - NLM
STAT- MEDLINE
DCOM- 20020422
LR  - 20200407
IS  - 0378-1135 (Print)
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 84
IP  - 1-2
DP  - 2002 Jan 3
TI  - Experimental inoculation of late term pregnant sows with a field isolate of 
      porcine reproductive and respiratory syndrome vaccine-derived virus.
PG  - 1-13
AB  - The use of a live attenuated porcine reproductive and respiratory syndrome virus 
      (PRRSV) vaccine in piglets has been associated with reproductive disorders in 
      non-vaccinated sows. Vaccine-derived virus (VDV) has been isolated from foetuses, 
      stillborn pigs, and dead piglets, indicating that the live vaccine spread from 
      vaccinated piglets to non-vaccinated sows, and that the virus might be implicated 
      in the severe reproductive problems observed. In the present study, one such VDV 
      isolate was used to experimentally infect pregnant sows in the last trimester. 
      The chosen isolate, which had more than 99.6% identity to the attenuated vaccine 
      virus, originated from the lungs of a stillborn pig from a swine herd with a 
      sudden high level of stillborn pigs and increased piglet mortality in the nursing 
      period. Intranasal inoculation of sows with the virus isolate resulted in 
      congenital infection, foetal death, and preweaning pig mortality. As such, the 
      present study showed that vaccine-derived PRRSV can cause disease in swine 
      consistent with PRRS.
FAU - Nielsen, J
AU  - Nielsen J
AD  - Danish Veterinary Institute for Virus Research, Lindholm, DK-4771 Kalvehave, 
      Denmark. jn@vetvirus.dk
FAU - Botner, A
AU  - Botner A
FAU - Bille-Hansen, V
AU  - Bille-Hansen V
FAU - Oleksiewicz, M B
AU  - Oleksiewicz MB
FAU - Storgaard, T
AU  - Storgaard T
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (DNA, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - DNA, Viral/analysis
MH  - Female
MH  - Fetal Death/etiology/veterinary
MH  - Lung/embryology/pathology/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*etiology/prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/immunology/isolation & 
      purification/*pathogenicity
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious/etiology/*veterinary
MH  - Reproduction
MH  - Reverse Transcriptase Polymerase Chain Reaction/veterinary
MH  - Swine
MH  - Vaccination/adverse effects/*veterinary
MH  - Vaccines, Attenuated/adverse effects
MH  - Viral Vaccines/*adverse effects
MH  - Virulence
PMC - PMC7117428
EDAT- 2001/12/04 10:00
MHDA- 2002/04/23 10:01
PMCR- 2001/11/27
CRDT- 2001/12/04 10:00
PHST- 2001/12/04 10:00 [pubmed]
PHST- 2002/04/23 10:01 [medline]
PHST- 2001/12/04 10:00 [entrez]
PHST- 2001/11/27 00:00 [pmc-release]
AID - S0378113501004503 [pii]
AID - S0378-1135(01)00450-3 [pii]
AID - 10.1016/s0378-1135(01)00450-3 [doi]
PST - ppublish
SO  - Vet Microbiol. 2002 Jan 3;84(1-2):1-13. doi: 10.1016/s0378-1135(01)00450-3.