PMID- 11731585
OWN - NLM
STAT- MEDLINE
DCOM- 20020211
LR  - 20190513
IS  - 0022-3751 (Print)
IS  - 1469-7793 (Electronic)
IS  - 0022-3751 (Linking)
VI  - 537
IP  - Pt 2
DP  - 2001 Dec 1
TI  - The temporal representation of the delay of iterated rippled noise in the ventral 
      cochlear nucleus of the guinea-pig.
PG  - 553-66
AB  - 1. We have examined the temporal discharge patterns of single units from the 
      ventral cochlear nucleus (VCN) of anaesthetized guinea-pigs in response to 
      iterated rippled noise (IRN). The pitch range evoked by the stimuli was from 32 
      to 1000 Hz. 2. Single units were classified into four groups using existing 
      classification schemes: primary-like (PL), onset (O), sustained chopper (CS) and 
      transient chopper (CT). For all unit types the delay of the IRN stimuli was well 
      represented in the all-order interspike interval histograms (ISIHs). 3. A subset 
      of the onset units (onset-chopper, OC) showed a clear preference for some delays 
      of the IRN in their first-order interval statistics. We describe this delay 
      preference as 'periodicity tuning'. The delay at which the pitch estimate was at 
      its maximum was designated its best periodicity. The range of best periodicities 
      for OC units was 3.75-13 ms (between 77 and 267 Hz). 4. The other unit types also 
      showed enhancement of the first-order interval statistics at the delay of the 
      IRN. The range of best periodicities was 1.4-8.8 ms (113-714 Hz) for the CT 
      group, 2.25-10.8 ms (93-444 Hz) for the CS group and 0.5-4.6 ms (217-2000 Hz) for 
      the PL group. 5. The correlation between the maximum interval enhancement 
      observed in response to the IRN stimuli and the peak in the first-order ISIH in 
      response to white noise was 0.81 for OC units, 0.72 for CS units, 0.44 for CT 
      units and -0.15 for PL units. 6. These results demonstrate that all unit types in 
      the VCN can enhance the representation of the delay of IRN using first-order 
      interspike intervals (ISIs) over a range of periodicities. CS and OC units show 
      the greatest range of best periodicities and they are well-suited to encode the 
      delay of IRN in their first-order ISIs for a wide range of pitches.
FAU - Winter, I M
AU  - Winter IM
AD  - Centre for the Neural Basis of Hearing, The Physiological Laboratory, Downing 
      Street, Cambridge CB2 3EG, UK. imw1001@cus.cam.ac.uk
FAU - Wiegrebe, L
AU  - Wiegrebe L
FAU - Patterson, R D
AU  - Patterson RD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Physiol
JT  - The Journal of physiology
JID - 0266262
SB  - IM
MH  - Action Potentials/physiology
MH  - Animals
MH  - Cochlear Nucleus/cytology/*physiology
MH  - Guinea Pigs
MH  - Neurons, Afferent/physiology
MH  - *Noise
MH  - Periodicity
MH  - Pitch Perception/physiology
MH  - Time Perception/*physiology
PMC - PMC2278959
EDAT- 2001/12/04 10:00
MHDA- 2002/02/12 10:01
PMCR- 2002/12/01
CRDT- 2001/12/04 10:00
PHST- 2001/12/04 10:00 [pubmed]
PHST- 2002/02/12 10:01 [medline]
PHST- 2001/12/04 10:00 [entrez]
PHST- 2002/12/01 00:00 [pmc-release]
AID - PHY_12973 [pii]
AID - 10.1111/j.1469-7793.2001.00553.x [doi]
PST - ppublish
SO  - J Physiol. 2001 Dec 1;537(Pt 2):553-66. doi: 10.1111/j.1469-7793.2001.00553.x.