PMID- 11732570
OWN - NLM
STAT- MEDLINE
DCOM- 20020103
LR  - 20071115
IS  - 1122-6714 (Print)
IS  - 1122-6714 (Linking)
VI  - 106
IP  - 2 Suppl 2
DP  - 2001
TI  - Ontogenesis of anti-oxidative enzymes in mouse embryos and fetuses: an 
      immunohistochemical study.
PG  - 137-42
AB  - The ontogenesis of two anti-oxidative enzymes, thioredoxin (TRX) and glutaredoxin 
      (GRX), was examined immunohistochemically in mouse embryos and fetuses at various 
      developmental stages. They were found to be localized in various tissues, with 
      some tissue specificity and temporal sequence. Both TRX and GRX began to be 
      expressed in many tissues at embryonic (E) day E10 or E11 and tended to increase 
      as the developmental stage advanced. In the heart and neuroepithelium, however, 
      their immunoreactivity was already positive at E8.5. In some fetal organs like 
      the liver, pancreas and kidney, TRX and GRX showed heterogeneous localization, 
      suggesting that their expression may reflect the variable functional states of 
      the cell. These results suggest that TRX and GRX may be associated with tissue 
      differentiation in embryos and fetuses are involved in the acquisition of the 
      capacity of resistance against oxygen radicals.
FAU - Kobayashi, M
AU  - Kobayashi M
AD  - Department of Anatomy and Developmental Biology, Institute of Virus Research, 
      Kyoto University, Japan.
FAU - Nakamura, H
AU  - Nakamura H
FAU - Yodoi, J
AU  - Yodoi J
FAU - Shiota, K
AU  - Shiota K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Ital J Anat Embryol
JT  - Italian journal of anatomy and embryology = Archivio italiano di anatomia ed 
      embriologia
JID - 9612303
RN  - 0 (Antioxidants)
RN  - 0 (Glutaredoxins)
RN  - 0 (Proteins)
RN  - 52500-60-4 (Thioredoxins)
RN  - EC 1.- (Oxidoreductases)
SB  - IM
MH  - Animals
MH  - *Antioxidants
MH  - Embryo, Mammalian/*enzymology
MH  - *Embryonic and Fetal Development
MH  - Epithelium/enzymology
MH  - Female
MH  - Gestational Age
MH  - Glutaredoxins
MH  - *Immunohistochemistry
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Myocardium/enzymology
MH  - Nervous System/embryology/enzymology
MH  - Organ Specificity
MH  - *Oxidoreductases
MH  - Pregnancy
MH  - Proteins/*analysis/metabolism
MH  - Thioredoxins/*analysis/metabolism
EDAT- 2001/12/06 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/12/06 10:00
PHST- 2001/12/06 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/12/06 10:00 [entrez]
PST - ppublish
SO  - Ital J Anat Embryol. 2001;106(2 Suppl 2):137-42.