PMID- 11734316
OWN - NLM
STAT- MEDLINE
DCOM- 20011228
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 131
IP  - 1
DP  - 2001 Nov
TI  - BCR/ABL fusion gene detected on 9q34 by fluorescence in situ hybridization in an 
      acute leukemia with two BCR/ABL positive clones, one Ph-negative and one 
      Ph-positive.
PG  - 37-41
AB  - We report cytogenetic, fluorescence in situ hybridization (FISH), and molecular 
      analyses in the first reported case of an acute leukemia with two BCR-positive 
      clones: one cell Ph-positive and all others Ph-negative. A BCR/ABL fusion gene on 
      9q34 was detected only with a BCR/ABL dual color translocation probe. These FISH 
      interphase signals must be confirmed on a metaphase to avoid an erroneous 
      interpretation. This observation appears to indicate a 2-step mechanism for this 
      aberrant fusion gene localization: first, a classical t(9;22), and then the 
      transfer of the fusion gene formed on chromosome 22 to chromosome 9 by a second 
      translocation between the long arms of the derivative chromosomes 9q+ and 22q-, 
      masking the first chromosome exchange.
FAU - Terre, C
AU  - Terre C
AD  - Laboratory of Biochemistry, Genetics and Hematology, Hopital de Versailles, 
      Versailles, France.
FAU - Bastie, J N
AU  - Bastie JN
FAU - Garcia, I
AU  - Garcia I
FAU - Suzan, F
AU  - Suzan F
FAU - Cayuela, J M
AU  - Cayuela JM
FAU - Therond, P
AU  - Therond P
FAU - Castaigne, S
AU  - Castaigne S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Acute Disease
MH  - Chromosomes, Human, Pair 22/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Clone Cells/pathology
MH  - Female
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Middle Aged
MH  - *Philadelphia Chromosome
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2001/12/06 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/12/06 10:00
PHST- 2001/12/06 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/12/06 10:00 [entrez]
AID - S0165-4608(01)00496-4 [pii]
AID - 10.1016/s0165-4608(01)00496-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2001 Nov;131(1):37-41. doi: 
      10.1016/s0165-4608(01)00496-4.