PMID- 11736935
OWN - NLM
STAT- MEDLINE
DCOM- 20020107
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 115
IP  - 3
DP  - 2001 Dec
TI  - MCP-1 modulates chemotaxis by follicular lymphoma cells.
PG  - 554-62
AB  - The localization and establishment of follicular lymphoma (FL) cells in distinct 
      anatomic sites probably involves chemokine and adhesion receptors on the 
      neoplastic cells and appropriate chemokines and adhesion receptor ligands in the 
      microenvironment. Several chemokines play an important role in normal B-cell 
      trafficking and differentiation. Monocyte chemoattractant protein-1 (MCP-1) is a 
      C-C chemokine that induces chemotaxis of a variety of lymphoid cells through its 
      receptor CCR2. CCR2 is also expressed on B cells, and MCP-1 induces chemotaxis of 
      normal B cells. In this report, we investigated expression and function of CCR2 
      on FL cells. We found FL cells as well as the t(14; 18)+ B-cell lymphoma line H2 
      expressed CCR2. MCP-1 potentiated SDF-1-induced chemotaxis of FL cells and H2 
      cells, but MCP-1 alone did not induce chemotaxis. The specificity of the effects 
      of MCP-1 and SDF-1 was demonstrated by antibody blocking studies. Because FL 
      cells are generally associated with follicular dendritic cells (FDCs), FDCs may 
      be an important source of chemokines. We found that cultured FDCs produced MCP-1, 
      and this production was enhanced by tumour necrosis factor. These data implicate 
      MCP-1 in the migration and localization of FL cells.
FAU - Husson, H
AU  - Husson H
AD  - Department of Medicine, Harvard Medical School, Dana-Farber Cancer Institute, 
      Boston, MA, USA.
FAU - Carideo, E G
AU  - Carideo EG
FAU - Cardoso, A A
AU  - Cardoso AA
FAU - Lugli, S M
AU  - Lugli SM
FAU - Neuberg, D
AU  - Neuberg D
FAU - Munoz, O
AU  - Munoz O
FAU - de Leval, L
AU  - de Leval L
FAU - Schultze, J
AU  - Schultze J
FAU - Freedman, A S
AU  - Freedman AS
LA  - eng
GR  - CA66996/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (CCR2 protein, human)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Receptors, CCR2)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Antibodies, Monoclonal/pharmacology
MH  - Cell Line
MH  - Chemokine CCL2/immunology/*pharmacology
MH  - Chemokine CXCL12
MH  - Chemokines, CXC/immunology/pharmacology
MH  - Chemotaxis, Leukocyte/*drug effects
MH  - Chromosomes, Human, Pair 14
MH  - Chromosomes, Human, Pair 18
MH  - Dendritic Cells, Follicular/metabolism
MH  - Drug Synergism
MH  - Flow Cytometry/methods
MH  - Humans
MH  - Lymphoma, B-Cell
MH  - Lymphoma, Follicular/immunology/*metabolism
MH  - Receptors, CCR2
MH  - Receptors, Chemokine/*analysis/metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Translocation, Genetic
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 2001/12/12 10:00
MHDA- 2002/01/10 10:01
CRDT- 2001/12/12 10:00
PHST- 2001/12/12 10:00 [pubmed]
PHST- 2002/01/10 10:01 [medline]
PHST- 2001/12/12 10:00 [entrez]
AID - 3145 [pii]
AID - 10.1046/j.1365-2141.2001.03145.x [doi]
PST - ppublish
SO  - Br J Haematol. 2001 Dec;115(3):554-62. doi: 10.1046/j.1365-2141.2001.03145.x.