PMID- 11737043
OWN - NLM
STAT- MEDLINE
DCOM- 20020306
LR  - 20190901
IS  - 0954-7894 (Print)
IS  - 0954-7894 (Linking)
VI  - 31
IP  - 12
DP  - 2001 Dec
TI  - The influence of inhalative corticosteroids on circulating Nerve Growth Factor, 
      Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics.
PG  - 1906-12
AB  - BACKGROUND: The neurotrophins Nerve Growth Factor (NGF), Brain-Derived 
      Neurotrophic Factor (BDNF) and Neurotrophin (NT)-3 are produced, stored and 
      released by various immunological cells. The influence of NTs upon the function 
      of these cells is described. Elevated plasma levels were found in inflammatory, 
      autoimmune and allergic diseases with the highest levels in allergic asthma. A 
      connection between bronchial hyper-responsiveness and serum levels has been 
      reported. OBJECTIVE: Little is known about the influence of treatment with 
      inhaled corticosteroids (ICS) on serum NT levels and their influence on the 
      asthmatic state. METHODS: Eighty-seven volunteers were studied. Thirty-eight were 
      stable allergic asthmatics with constant ICS doses, 29 were asthmatics not 
      receiving anti-asthmatic treatment and 20 were age- and sex-matched healthy 
      controls. Demographic and lung function data were evaluated. NT serum levels were 
      determined by ELISA. RESULTS: NGF and BDNF levels were significantly increased in 
      untreated asthmatics compared to the control and the treated group, while NT-3 
      demonstrated significantly higher levels in treated asthmatics compared to 
      healthy controls. After stabilization of untreated subjects with ICS, the NT 
      levels decreased significantly. CONCLUSIONS: These results suggest that NTs 
      participate in allergic inflammation and asthma. Effective treatment leads to a 
      decrease of circulating neurotrophic factors.
FAU - Noga, O
AU  - Noga O
AD  - Allergy and Asthma Clinic, Charite-Campus Virchow, Humboldt University Berlin, 
      Germany. onoga@charite.de
FAU - Hanf, G
AU  - Hanf G
FAU - Schaper, C
AU  - Schaper C
FAU - O'Connor, A
AU  - O'Connor A
FAU - Kunkel, G
AU  - Kunkel G
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adrenal Cortex Hormones/*therapeutic use
MH  - Adult
MH  - Asthma/*drug therapy/*immunology
MH  - Blood Circulation/*drug effects/*immunology
MH  - Brain-Derived Neurotrophic Factor/*blood/*drug effects
MH  - Female
MH  - Forced Expiratory Volume/drug effects/physiology
MH  - Humans
MH  - Lung/blood supply/drug effects
MH  - Male
MH  - Nerve Growth Factor/*blood/*drug effects
MH  - Neurotrophin 3/*blood/*drug effects
MH  - Reference Values
MH  - Respiratory Function Tests
MH  - Respiratory Hypersensitivity/*drug therapy
MH  - *Respiratory Therapy
EDAT- 2001/12/12 10:00
MHDA- 2002/03/07 10:01
CRDT- 2001/12/12 10:00
PHST- 2001/12/12 10:00 [pubmed]
PHST- 2002/03/07 10:01 [medline]
PHST- 2001/12/12 10:00 [entrez]
AID - 1249 [pii]
AID - 10.1046/j.1365-2222.2001.01249.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2001 Dec;31(12):1906-12. doi: 10.1046/j.1365-2222.2001.01249.x.