PMID- 11737239
OWN - NLM
STAT- MEDLINE
DCOM- 20020412
LR  - 20190826
IS  - 0014-2972 (Print)
IS  - 0014-2972 (Linking)
VI  - 31
IP  - 11
DP  - 2001 Nov
TI  - Surfing the insulin signaling web.
PG  - 966-77
AB  - The diverse biological actions of insulin and insulin-like growth factor I 
      (IGF-I) are initiated by binding of the polypeptides to their respective cell 
      surface tyrosine kinase receptors. These activated receptors phosphorylate a 
      series of endogenous substrates on tyrosine, amongst which the insulin receptor 
      substrate (IRS) proteins are the best characterized. Their 
      phosphotyrosine-containing motifs become binding sites for Src homology 2 (SH2) 
      domains on proteins such as SH2 domain-containing protein-tyrosine-phosphatase 
      (SHP)-2/Syp, growth factor receptor bound-2 protein, (Grb-2), and phosphatidyl 
      inositol 3 kinase (PI3 kinase), which participate in activation of specific 
      signaling cascades. However, the IRS molecules are not only platforms for 
      signaling molecules, they also orchestrate the generation of signal specificity, 
      integration of signals induced by several extracellular stimuli, and signal 
      termination and modulation. An extensive review is beyond the scope of the 
      present article, which will be centered on our own contribution and reflect our 
      biases.
FAU - Van Obberghen, E
AU  - Van Obberghen E
AD  - Inserm U 145, IFR 50, Faculte de Medecine, Avenue de Valombrose, Nice Cedex, 
      France. vanobbeg@unice.fr
FAU - Baron, V
AU  - Baron V
FAU - Delahaye, L
AU  - Delahaye L
FAU - Emanuelli, B
AU  - Emanuelli B
FAU - Filippa, N
AU  - Filippa N
FAU - Giorgetti-Peraldi, S
AU  - Giorgetti-Peraldi S
FAU - Lebrun, P
AU  - Lebrun P
FAU - Mothe-Satney, I
AU  - Mothe-Satney I
FAU - Peraldi, P
AU  - Peraldi P
FAU - Rocchi, S
AU  - Rocchi S
FAU - Sawka-Verhelle, D
AU  - Sawka-Verhelle D
FAU - Tartare-Deckert, S
AU  - Tartare-Deckert S
FAU - Giudicelli, J
AU  - Giudicelli J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Eur J Clin Invest
JT  - European journal of clinical investigation
JID - 0245331
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (GAB1 protein, human)
RN  - 0 (Insulin)
RN  - 0 (Integrins)
RN  - 0 (Milk Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (SOCS3 protein, human)
RN  - 0 (STAT5 Transcription Factor)
RN  - 0 (Suppressor of Cytokine Signaling 3 Protein)
RN  - 0 (Suppressor of Cytokine Signaling Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - DNA-Binding Proteins/metabolism
MH  - Humans
MH  - Insulin/*metabolism
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Integrins/metabolism
MH  - *Milk Proteins
MH  - Models, Biological
MH  - Phosphoproteins/metabolism
MH  - Protein Structure, Tertiary
MH  - Proteins/metabolism
MH  - Receptor, IGF Type 1/*metabolism
MH  - *Repressor Proteins
MH  - STAT5 Transcription Factor
MH  - Signal Transduction/*physiology
MH  - Suppressor of Cytokine Signaling 3 Protein
MH  - Suppressor of Cytokine Signaling Proteins
MH  - Trans-Activators/metabolism
MH  - *Transcription Factors
RF  - 87
EDAT- 2001/12/12 10:00
MHDA- 2002/04/16 10:01
CRDT- 2001/12/12 10:00
PHST- 2001/12/12 10:00 [pubmed]
PHST- 2002/04/16 10:01 [medline]
PHST- 2001/12/12 10:00 [entrez]
AID - 896 [pii]
AID - 10.1046/j.1365-2362.2001.00896.x [doi]
PST - ppublish
SO  - Eur J Clin Invest. 2001 Nov;31(11):966-77. doi: 10.1046/j.1365-2362.2001.00896.x.