PMID- 11737357
OWN - NLM
STAT- MEDLINE
DCOM- 20020212
LR  - 20191105
IS  - 1464-2662 (Print)
IS  - 1464-2662 (Linking)
VI  - 1
IP  - 4
DP  - 2000 Oct
TI  - Is acute appendicitis another inflammatory condition associated with highly 
      active antiretroviral therapy (HAART)?
PG  - 252-5
AB  - OBJECTIVE: To report the occurrence of acute appendicitis as a possible 
      manifestation of the immune restoration inflammatory syndrome (IRIS) following 
      the commencement of highly active antiretroviral therapy (HAART) in HIV patients. 
      DESIGN: Case-note review of HIV patients on HAART with acute appendicitis. 
      METHODS: Review of HIV markers, antiretroviral therapy and abdominal ultrasound 
      results of four HIV patients with acute appendicitis and the histopathology 
      reports on the appendix in two of the patients. RESULTS: From a population of 
      approximately 350 HIV patients on HAART, we found four patients who developed 
      acute appendicitis within 6 months of commencing or changing HAART. CONCLUSION: 
      Acute appendicitis occurring in HIV patients on HAART may represent a variant of 
      IRIS. Further immunohistopathological and epidemiological evaluation will be 
      needed to define this relationship fully.
FAU - Aldeen, T
AU  - Aldeen T
AD  - Department of Genitourinary Medicine, St George's Hospital, London, UK.
FAU - Horgan, M
AU  - Horgan M
FAU - Macallan, D C
AU  - Macallan DC
FAU - Thomas, V
AU  - Thomas V
FAU - Hay, P
AU  - Hay P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - HIV Med
JT  - HIV medicine
JID - 100897392
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Appendicitis/*chemically induced/*immunology/physiopathology
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Immunocompromised Host
MH  - Inflammation/physiopathology
MH  - Male
MH  - Middle Aged
EDAT- 2001/12/12 10:00
MHDA- 2002/02/13 10:01
CRDT- 2001/12/12 10:00
PHST- 2001/12/12 10:00 [pubmed]
PHST- 2002/02/13 10:01 [medline]
PHST- 2001/12/12 10:00 [entrez]
AID - hiv037 [pii]
AID - 10.1046/j.1468-1293.2000.00037.x [doi]
PST - ppublish
SO  - HIV Med. 2000 Oct;1(4):252-5. doi: 10.1046/j.1468-1293.2000.00037.x.