PMID- 11737675
OWN - NLM
STAT- MEDLINE
DCOM- 20020226
LR  - 20191105
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 12
IP  - 5
DP  - 2001 Oct
TI  - Positive skin and oral challenge responses to potato and occurrence of 
      immunoglobulin E antibodies to patatin (Sol t 1) in infants with atopic 
      dermatitis.
PG  - 283-8
AB  - The clinical significance and molecular specificity of hypersensitivity reactions 
      to raw and cooked potatoes remain ambiguous. We therefore investigated the 
      clinical hypersensitivity to raw and cooked potato in infants suspected to have 
      potato allergy and compared the findings with the occurrence of immunoglobulin E 
      (IgE) antibodies to patatin (Sol t 1), characterized as the primary allergen of 
      potato. Twelve infants (10 to 24 months of age) suffering from atopic dermatitis 
      (AD) and suspected to have adverse reactions to potato, were examined. As a skin 
      exposure test we used rubbing with both raw and cooked potato, and used open oral 
      challenge with cooked potato for 7 days. A special eczema scoring system (SCORAD) 
      was used to assess the severity of symptoms and signs of AD. Skin-prick tests 
      (SPTs) were performed with raw potato and natural Sol t 1, and serological 
      studies included measurement of total serum IgE and IgE antibodies to Sol t 1, 
      and potato radioallergosorbent testing (RAST). The skin-rubbing test with raw 
      potato was positive in seven (58%) and the oral challenge positive in eight (67%) 
      infants. One infant presented with an immediate reaction and seven with a delayed 
      reaction, i.e. exacerbation of AD, after oral challenge responses to cooked 
      potato. Nine (75%) infants had IgE antibodies to Sol t 1 in enzyme-linked 
      immunosorbent assay (ELISA), and SPT to natural Sol t 1 was positive in six (50%) 
      potato-allergic infants. In conclusion, we observed positive challenge responses 
      to both raw and cooked potato in food-allergic atopic infants. The presence of 
      IgE antibodies and concomitant positive SPTs to the heat-stable potato allergen, 
      Sol t 1, suggest that cooked potato can be an allergenic food for infants 
      suffering from AD.
FAU - Majamaa, H
AU  - Majamaa H
AD  - Department of Dermatology, Tampere University Hospital and University of Tampere, 
      Finland. heli.majamaa@tays.fi
FAU - Seppala, U
AU  - Seppala U
FAU - Palosuo, T
AU  - Palosuo T
FAU - Turjanmaa, K
AU  - Turjanmaa K
FAU - Kalkkinen, N
AU  - Kalkkinen N
FAU - Reunala, T
AU  - Reunala T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Plant Proteins)
RN  - 0 (anti-IgE antibodies)
RN  - 0 (patatin protein, Solanum tuberosum)
RN  - EC 3.1.1.- (Carboxylic Ester Hydrolases)
SB  - IM
MH  - Administration, Oral
MH  - Allergens/*adverse effects/*immunology
MH  - Antibodies, Anti-Idiotypic/*immunology
MH  - Carboxylic Ester Hydrolases/*immunology
MH  - Dermatitis, Atopic/*immunology
MH  - Double-Blind Method
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Food Hypersensitivity/*immunology
MH  - Humans
MH  - Immunoblotting
MH  - Infant
MH  - Infant Welfare
MH  - Male
MH  - Plant Proteins/*immunology
MH  - Radioallergosorbent Test
MH  - Skin/*immunology
MH  - Skin Tests
MH  - Solanum tuberosum/*adverse effects
EDAT- 2001/12/12 10:00
MHDA- 2002/02/28 10:01
CRDT- 2001/12/12 10:00
PHST- 2001/12/12 10:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2001/12/12 10:00 [entrez]
AID - 096 [pii]
AID - 10.1034/j.1399-3038.2001.00096.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2001 Oct;12(5):283-8. doi: 
      10.1034/j.1399-3038.2001.00096.x.