PMID- 11738389
OWN - NLM
STAT- MEDLINE
DCOM- 20020104
LR  - 20190906
IS  - 0009-9120 (Print)
IS  - 0009-9120 (Linking)
VI  - 34
IP  - 7
DP  - 2001 Oct
TI  - Serum total sialic acid in cholangiocarcinoma patients: an ROC curve analysis.
PG  - 537-41
AB  - OBJECTIVES: This study was undertaken to establish the diagnostic utility of 
      serum total sialic acid (TSA) for patients with cholangiocarcinoma (CCA). DESIGN 
      AND METHODS: Serum TSA was determined in 89 histologically confirmed CCA 
      patients, 38 with benign hepatobiliary diseases (BHD) and 43 healthy persons. To 
      check whether the test could adequately discriminate between these groups, 
      complete statistical Receiver Operating Characteristic (ROC) curves were 
      analyzed. RESULTS: The mean value of serum TSA in CCA patients (2.75 +/- 0.67 
      mmol/L) was significantly higher than that in the BHD (2.33 +/- 0.69 mmol/L p < 
      0.002) and healthy persons (1.89 +/- 0.46 mmol/L p < 0.001) groups. The areas 
      under the ROC curves were 0.6699 and 0.8558, respectively. A cut-off value of 
      2.33 mmol/L discriminated between the CCA, BHD and healthy groups with a 
      sensitivity of 71.9% and a positive predictive value range of 80 to 89%. 
      CONCLUSION: Determination of TSA yielded high diagnostic values for 
      differentiating between CCA, BHD and healthy persons. The determination of serum 
      TSA would be most useful as an adjunct diagnosis rather than an early detection 
      and screening tool because of the apparent nonspecificity of SA to a given 
      disease.
FAU - Wongkham, S
AU  - Wongkham S
AD  - Department of Biochemistry, Cholangiocarcinoma Research Group, Faculty of 
      Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. sopit@kku.ac.th
FAU - Boonla, C
AU  - Boonla C
FAU - Kongkham, S
AU  - Kongkham S
FAU - Wongkham, C
AU  - Wongkham C
FAU - Bhudhisawasdi, V
AU  - Bhudhisawasdi V
FAU - Sripa, B
AU  - Sripa B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - GZP2782OP0 (N-Acetylneuraminic Acid)
SB  - IM
MH  - Bile Duct Neoplasms/*blood
MH  - Bile Ducts, Intrahepatic/*metabolism
MH  - Cholangiocarcinoma/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - N-Acetylneuraminic Acid/*blood
EDAT- 2001/12/12 10:00
MHDA- 2002/01/10 10:01
CRDT- 2001/12/12 10:00
PHST- 2001/12/12 10:00 [pubmed]
PHST- 2002/01/10 10:01 [medline]
PHST- 2001/12/12 10:00 [entrez]
AID - S0009-9120(01)00265-X [pii]
AID - 10.1016/s0009-9120(01)00265-x [doi]
PST - ppublish
SO  - Clin Biochem. 2001 Oct;34(7):537-41. doi: 10.1016/s0009-9120(01)00265-x.