PMID- 11740307
OWN - NLM
STAT- MEDLINE
DCOM- 20020117
LR  - 20220331
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 33
IP  - 12
DP  - 2001 Dec
TI  - Creatine supplementation combined with resistance training in older men.
PG  - 2111-7
AB  - PURPOSE: To study the effect of creatine (Cr) supplementation combined with 
      resistance training on muscular performance and body composition in older men. 
      METHODS: Thirty men were randomized to receive creatine supplementation (CRE, N = 
      16, age = 70.4 +/- 1.6 yr) or placebo (PLA, N = 14, age = 71.1 +/- 1.8 yr), using 
      a double blind procedure. Cr supplementation consisted of 0.3-g Cr.kg(-1) body 
      weight for the first 5 d (loading phase) and 0.07-g Cr.kg(-1) body weight 
      thereafter. Both groups participated in resistance training (36 sessions, 3 times 
      per week, 3 sets of 10 repetitions, 12 exercises). Muscular strength was assessed 
      by 1-repetition maximum (1-RM) for leg press (LP), knee extension (KE), and bench 
      press (BP). Muscular endurance was assessed by the maximum number of repetitions 
      over 3 sets (separated by 1-min rest intervals) at an intensity corresponding to 
      70% baseline 1-RM for BP and 80% baseline 1-RM for the KE and LP. Average power 
      (AP) was assessed using a Biodex isokinetic knee extension/flexion exercise (3 
      sets of 10 repetitions at 60 degrees.s(-1) separated by 1-min rest). Lean tissue 
      (LTM) and fat mass were assessed using dual energy x-ray absorptiometry. RESULTS: 
      Compared with PLA, the CRE group had significantly greater increases in LTM (CRE, 
      +3.3 kg; PLA, +1.3 kg), LP 1-RM (CRE, +50.1 kg; PLA +31.3 kg), KE 1-RM (CRE, 
      +14.9 kg; PLA, +10.7 kg), LP endurance (CRE, +47 reps; PLA, +32 reps), KE 
      endurance (CRE, +21 reps; PLA +14 reps), and AP (CRE, +26.7 W; PLA, +18 W). 
      Changes in fat mass, fat percentage, BP 1-RM, and BP endurance were similar 
      between groups. CONCLUSION: Creatine supplementation, when combined with 
      resistance training, increases lean tissue mass and improves leg strength, 
      endurance, and average power in men of mean age 70 yr.
FAU - Chrusch, M J
AU  - Chrusch MJ
AD  - College of Kinesiology, University of Saskatchewan, 105 Gymnasium Place, 
      Saskatoon, Saskatchewan, S7N 5C2, Canada.
FAU - Chilibeck, P D
AU  - Chilibeck PD
FAU - Chad, K E
AU  - Chad KE
FAU - Davison, K S
AU  - Davison KS
FAU - Burke, D G
AU  - Burke DG
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - MU72812GK0 (Creatine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Body Composition/*drug effects
MH  - Creatine/adverse effects/*pharmacology
MH  - Diarrhea/chemically induced
MH  - Double-Blind Method
MH  - Exercise/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Cramp/chemically induced
MH  - Muscle, Skeletal/*drug effects
MH  - Physical Endurance/*drug effects
MH  - Task Performance and Analysis
MH  - Weight Lifting/*physiology
EDAT- 2001/12/12 10:00
MHDA- 2002/01/18 10:01
CRDT- 2001/12/12 10:00
PHST- 2001/12/12 10:00 [pubmed]
PHST- 2002/01/18 10:01 [medline]
PHST- 2001/12/12 10:00 [entrez]
AID - 10.1097/00005768-200112000-00021 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2001 Dec;33(12):2111-7. doi: 
      10.1097/00005768-200112000-00021.