PMID- 11740980
OWN - NLM
STAT- MEDLINE
DCOM- 20020226
LR  - 20220311
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 105
IP  - 1-2
DP  - 2001 Dec 15
TI  - Combined ECT and neuroleptic therapy in treatment-refractory schizophrenia: 
      prediction of outcome.
PG  - 107-15
AB  - There have been scanty reports of the clinical features of schizophrenic patients 
      treated with electroconvulsive therapy (ECT). This prospective study examined 
      clinical characteristics and predictive factors associated with therapeutic 
      outcome. Two hundred and ninety-three patients with refractory schizophrenia were 
      treated with a combination of ECT and flupenthixol. Outcome assessments included 
      the Brief Psychiatric Rating Scale (BPRS), the Global Assessment of Functioning 
      (GAF), and the Mini-Mental State Examination (MMSE). One hundred and sixty 
      patients (54.6%) met a response criterion. The responders were younger, had 
      shorter durations of illness and current episode, more admissions, and less 
      family history of schizophrenia. The duration of current episode (t=5.0, 
      P<0.0001), followed by baseline GAF score (t=3.1, P=0.002), duration of illness 
      (t=3.1, P=0.002), baseline MMSE score (t=3.0, P=0.003), duration of the 
      previously failed neuroleptic trials (t=3.0, P=0.003), family history of 
      schizophrenia (t=2.1, P=0.03), and paranoid type (t=2.1, P=0.04), could predict 
      the therapeutic outcome. Treatment resulted in marked improvement in positive 
      symptoms but had a minimal effect or led to a worsening of negative symptoms.
FAU - Chanpattana, W
AU  - Chanpattana W
AD  - Department of Psychiatry, Srinakharinwirot University, 681 Samsen, Dusit, 10300, 
      Bangkok, Thailand. worch@loxinfo.co.th
FAU - Chakrabhand, M L
AU  - Chakrabhand ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - FA0UYH6QUO (Flupenthixol)
SB  - IM
MH  - Adult
MH  - Combined Modality Therapy
MH  - *Electroconvulsive Therapy
MH  - Female
MH  - Flupenthixol/*therapeutic use
MH  - Humans
MH  - Male
MH  - Mental Status Schedule
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/diagnosis/genetics/*therapy
MH  - *Schizophrenic Psychology
MH  - Treatment Outcome
EDAT- 2001/12/13 10:00
MHDA- 2002/02/28 10:01
CRDT- 2001/12/13 10:00
PHST- 2001/12/13 10:00 [pubmed]
PHST- 2002/02/28 10:01 [medline]
PHST- 2001/12/13 10:00 [entrez]
AID - S0165178101003213 [pii]
AID - 10.1016/s0165-1781(01)00321-3 [doi]
PST - ppublish
SO  - Psychiatry Res. 2001 Dec 15;105(1-2):107-15. doi: 10.1016/s0165-1781(01)00321-3.