PMID- 11743140
OWN - NLM
STAT- MEDLINE
DCOM- 20020107
LR  - 20190607
IS  - 1535-3702 (Print)
IS  - 1535-3699 (Linking)
VI  - 226
IP  - 11
DP  - 2001 Dec
TI  - High glycemic index carbohydrate diet alters the diurnal rhythm of leptin but not 
      insulin concentrations.
PG  - 1037-44
AB  - Morning serum leptin values in humans are inconsistently altered by diet, and the 
      molecular mechanisms controlling the diurnal leptin pattern remain unexplained. 
      We determined whether leptin values after meals or the leptin diurnal pattern was 
      altered by the type of carbohydrate (CHO) ingested in diets containing either 20% 
      or 30% fat. In a randomized, crossover study design, nine healthy lean adults ate 
      one of four isocaloric diets for 8 days. Diets contained 15% protein: A, high 
      glycemic index (GI) CHO, 30% fat; B, low GI CHO, 30% fat; C, high GI CHO, 20% 
      fat; and D, low GI CHO, 20% fat. Serum glucose, insulin, and leptin were measured 
      at intervals on Day 8 for 24 hr, and on Day 9 during an oral glucose tolerance 
      test (GTT). Although the 24-hr glucose and insulin profiles did not differ with 
      the diets, diets A and C altered the serum leptin diurnal pattern. In contrast to 
      the usual evening rise in leptin concentration, which begins after 2200 hr, diets 
      A and C caused a rise in leptin beginning at 1300 hr. The area under the curve 
      for leptin between 1230 and 2400 hr was 17% greater for diets A and C. During the 
      GTT, leptin concentrations were similar for each diet. These results suggest that 
      the pattern and amount of leptin secretion may be altered by high GI CHO or the 
      simple sugar content of the diet, unrelated to differences in insulin 
      concentration, that high GI foods may have little or no effect on serum insulin 
      in the context of a mixed meal, and that a single 0800-hr leptin value may not be 
      sufficient to reveal a diet-induced change in leptin secretion
FAU - Herrmann, T S
AU  - Herrmann TS
AD  - Department of Nutrition, University of North Carolina, Chapel Hill, North 
      Carolina 27599, USA.
FAU - Bean, M L
AU  - Bean ML
FAU - Black, T M
AU  - Black TM
FAU - Wang, P
AU  - Wang P
FAU - Coleman, R A
AU  - Coleman RA
LA  - eng
GR  - DK56350/DK/NIDDK NIH HHS/United States
GR  - M01 RR00046/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Exp Biol Med (Maywood)
JT  - Experimental biology and medicine (Maywood, N.J.)
JID - 100973463
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, Dietary)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - *Carbohydrate Metabolism
MH  - Cholesterol, Dietary/metabolism
MH  - Circadian Rhythm
MH  - Cross-Over Studies
MH  - *Diet
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/*metabolism/*physiology
MH  - Insulin Secretion
MH  - Leptin/*metabolism/*physiology
MH  - Male
MH  - Random Allocation
MH  - Time Factors
EDAT- 2001/12/18 10:00
MHDA- 2002/01/10 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/01/10 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - 10.1177/153537020122601111 [doi]
PST - ppublish
SO  - Exp Biol Med (Maywood). 2001 Dec;226(11):1037-44. doi: 
      10.1177/153537020122601111.