PMID- 11743997
OWN - NLM
STAT- MEDLINE
DCOM- 20020227
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 924
IP  - 1
DP  - 2002 Jan 4
TI  - Ethanol-induced alterations of neurotrophin receptor expression on Purkinje cells 
      in the neonatal rat cerebellum.
PG  - 71-81
AB  - Ethanol causes loss of Purkinje cells in the cerebellum during the early stages 
      of differentiation and maturation by a presently unknown mechanism. Neuronal 
      vulnerability in the cerebellum parallels the prominent temporal and anatomical 
      gradients of development (i.e. early to late interlobular and posterior to 
      anterior, respectively). Development of Purkinje cells is known to require 
      binding of the neurotrophins, including brain-derived neurotrophic factor (BDNF) 
      and neurotrophin-3 (NT3), to the tyrosine-kinase (Trk) receptors TrkB and TrkC, 
      respectively. In addition, Purkinje cells are reported to experience a critical 
      switch between BDNF dependence and NT3 dependence during the period of highest 
      ethanol sensitivity between postnatal days (PN) 4-6. To test the hypothesis that 
      ethanol alters neurotrophin signaling leading to Purkinje neuronal death, the 
      immunohistochemical expression of TrkB and TrkC receptors on Purkinje cells of 
      rat pups following a moderate dose of ethanol was determined at various times 
      surrounding the period of postnatal ethanol vulnerability. Ethanol selectively 
      decreased Purkinje cell expression of TrkB and TrkC receptors following exposures 
      within the vulnerable period (PN4-6). These results suggest that ethanol may 
      induce loss of Purkinje cells by alteration of neurotrophic regulation at this 
      critical stage.
FAU - Light, Kim E
AU  - Light KE
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, University of 
      Arkansas for Medical Sciences, 4301 W. Markham, Little Rock, AR 72205, USA. 
      lightkime@uams.edu
FAU - Brown, Donna P
AU  - Brown DP
FAU - Newton, Bruce W
AU  - Newton BW
FAU - Belcher, Scott M
AU  - Belcher SM
FAU - Kane, Cynthia J M
AU  - Kane CJ
LA  - eng
GR  - AA 12623/AA/NIAAA NIH HHS/United States
GR  - AA 12756/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 3K9958V90M (Ethanol)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Alcohol-Induced Disorders, Nervous System/metabolism/physiopathology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Differentiation/*drug effects/physiology
MH  - Cerebellar Cortex/*drug effects/growth & development/pathology
MH  - Ethanol/*pharmacology
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/metabolism/physiopathology
MH  - Immunohistochemistry
MH  - Male
MH  - Nerve Degeneration/*chemically induced/metabolism/physiopathology
MH  - Nerve Growth Factors/*metabolism
MH  - Neurotrophin 3/metabolism
MH  - Pregnancy
MH  - Purkinje Cells/*drug effects/metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
MH  - Receptor, trkC/metabolism
MH  - Receptors, Nerve Growth Factor/*drug effects/metabolism
EDAT- 2001/12/18 10:00
MHDA- 2002/03/19 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/03/19 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - S0006899301032243 [pii]
AID - 10.1016/s0006-8993(01)03224-3 [doi]
PST - ppublish
SO  - Brain Res. 2002 Jan 4;924(1):71-81. doi: 10.1016/s0006-8993(01)03224-3.