PMID- 11744227
OWN - NLM
STAT- MEDLINE
DCOM- 20020227
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 316
IP  - 3
DP  - 2001 Dec 28
TI  - Unipolar brush cells in the human cochlear nuclei identified by their expression 
      of a metabotropic glutamate receptor (mGluR2/3).
PG  - 161-4
AB  - Unipolar brush cells (UBCs) reside in the mammalian vestibulo-cerebellum and the 
      ventral (VCN) and, particularly, dorsal cochlear nuclei (DCN). Human cerebellar 
      UBCs are numerous too, but auditory UBCs have escaped detection. The human DCN, 
      considered a degenerated structure, lost lamination and possibly neurons common 
      in lower mammals, like UBCs. We searched for human auditory UBCs probing their 
      immunoreactivity against the calcium-binding protein calretinin (CR-IR), and a 
      metabotropic glutamate receptor (mGluR2/3-IR). We found: UBCs are constituents of 
      the human DCN and VCN, though in small numbers. These auditory UBCs are not 
      CR-IR, in contrast to human cerebellar UBCs and cerebellar and auditory UBCs in 
      non-primate mammals, but display mGluR2/3-IR. The human DCN, thus, appears more 
      complete than previously thought. This may be of interest regarding auditory 
      brainstem electrode implantations in deaf patients.
FAU - Spatz, W B
AU  - Spatz WB
AD  - Morphological Brain Research, Department of Oto-Rhino-Laryngology, University of 
      Freiburg, Killianstrasse 5, 79106 Freiburg, Germany. 
      spatz@hno1.ukl.uni-freiburg.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (metabotropic glutamate receptor 2)
RN  - 0 (metabotropic glutamate receptor 3)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Adult
MH  - Auditory Perception/*physiology
MH  - Cell Size/physiology
MH  - Cochlear Nucleus/*cytology/*metabolism
MH  - Dendrites/metabolism/ultrastructure
MH  - Glutamic Acid/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Neural Pathways/physiology
MH  - Neurons/*cytology/*metabolism
MH  - Receptors, Metabotropic Glutamate/*metabolism
MH  - Synaptic Transmission/physiology
EDAT- 2001/12/18 10:00
MHDA- 2002/03/19 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/03/19 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - S0304394001023928 [pii]
AID - 10.1016/s0304-3940(01)02392-8 [doi]
PST - ppublish
SO  - Neurosci Lett. 2001 Dec 28;316(3):161-4. doi: 10.1016/s0304-3940(01)02392-8.