PMID- 11744389
OWN - NLM
STAT- MEDLINE
DCOM- 20020510
LR  - 20190910
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 110
IP  - 1-2
DP  - 2002 Jan
TI  - Expression pattern of the single-minded gene in zebrafish embryos.
PG  - 231-5
AB  - Recently we isolated a homolog of the Drosophila single-minded (sim) gene from a 
      zebrafish cDNA library. The 4380-bp of zebrafish sim cDNA encodes a polypeptide 
      of 585 amino acids with strikingly conserved bHLH and PAS A/B domains in the 
      amino-terminal region. During embryogenesis, sim mRNA appears in the animal 
      hemisphere as early as 3 h post-fertilization and is expressed in a widespread 
      pattern throughout the epiblast at the 75% epiboly stage. During the segmentation 
      stage, sim mRNA is prominently expressed in the primordium of the hindbrain and 
      appears as a transverse stripe in the epithelial layers of the mid-diencephalic 
      boundary (MDB). During the pharyngula stage, sim is no longer expressed in the 
      hindbrain, but continues to be expressed in the MDB and extends to the caudal 
      diencephalon along the ventral midline. In addition, sim mRNA is prominent in the 
      two pharyngeal arches. During the larval stage, sim mRNA is transcribed in the 
      esophagus, liver, pancreas, and intestine. In contrast, sim mRNA is no longer 
      detectable in the forebrain after hatching. In adult fish, sim is widely 
      expressed in brain, eyes, gill, heart, liver, and intestine.
FAU - Wen, Hui-Ju
AU  - Wen HJ
AD  - Institute of Marine Biotechnology, National Taiwan Ocean University, No. 2, 
      Pei-Ning Road, Keelung 202-24, Taiwan.
FAU - Wang, Ying
AU  - Wang Y
FAU - Chen, Sei-Hui
AU  - Chen SH
FAU - Hu, Chin-Hwa
AU  - Hu CH
LA  - eng
SI  - GENBANK/AF363019
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA, Complementary)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (sim protein, Drosophila)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - DNA, Complementary/genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Drosophila Proteins
MH  - Gene Expression Regulation, Developmental
MH  - In Situ Hybridization
MH  - Larva/growth & development/metabolism
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/*genetics
MH  - Organ Specificity
MH  - RNA, Messenger/genetics/metabolism
MH  - Zebrafish/*embryology/*genetics/growth & development
EDAT- 2001/12/18 10:00
MHDA- 2002/05/11 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/05/11 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - S0925477301005822 [pii]
AID - 10.1016/s0925-4773(01)00582-2 [doi]
PST - ppublish
SO  - Mech Dev. 2002 Jan;110(1-2):231-5. doi: 10.1016/s0925-4773(01)00582-2.