PMID- 11744483
OWN - NLM
STAT- MEDLINE
DCOM- 20020102
LR  - 20190714
IS  - 1527-9995 (Electronic)
IS  - 0090-4295 (Linking)
VI  - 58
IP  - 6
DP  - 2001 Dec
TI  - Susceptibility to vesicoureteral reflux in Japanese is linked to HLA-DR antigen.
PG  - 1036-40
AB  - OBJECTIVES: To determine whether vesicoureteral reflux is associated with the 
      human leukocyte antigen (HLA) genes. METHODS: We evaluated 40 Japanese patients 
      (27 males and 13 females) with reflux. HLA-DR low-resolution genotyping and 
      high-resolution typing of HLA-DRB1 alleles were performed. The frequencies of the 
      HLAs and alleles were calculated and compared with those previously reported in 
      493 healthy Japanese. RESULTS: Low-resolution typing showed that the frequency of 
      the HLA-DR11 antigen was significantly higher in the patients with reflux than in 
      the control group. High-resolution typing revealed that the frequencies of 
      HLA-DRB1*1101 and 1502 alleles were significantly higher in the patients with 
      reflux than in the control group. In the patients with and without renal 
      scarring, the frequencies of the HLA-DR11 antigens and HLA-DRB1*1101 alleles were 
      significantly lower in those with renal scarring. In the patients with and 
      without the chief complaint of urinary tract infection symptoms, the frequencies 
      of HLA-DR13 antigens and HLA-DRB1*1302 alleles were significantly lower in those 
      with that chief complaint. CONCLUSIONS: The susceptibility to reflux is, in part, 
      controlled by HLA genes themselves or an unknown gene or genes, the locus for 
      which is located close to the DRB1 gene. The lack of a HLA-DRB1*1101 allele and 
      DRB1*1302 allele in patients with reflux might be connected with renal scarring 
      and urinary tract infection, respectively.
FAU - Kawauchi, A
AU  - Kawauchi A
AD  - Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
FAU - Takahara, S
AU  - Takahara S
FAU - Sada, M
AU  - Sada M
FAU - Goto, R
AU  - Goto R
FAU - Nakatani, T
AU  - Nakatani T
FAU - Miki, T
AU  - Miki T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Urology
JT  - Urology
JID - 0366151
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR11 antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR Serological Subtypes
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Infant
MH  - Japan/ethnology
MH  - Male
MH  - Odds Ratio
MH  - Vesico-Ureteral Reflux/*genetics
EDAT- 2001/12/18 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - S0090429501014595 [pii]
AID - 10.1016/s0090-4295(01)01459-5 [doi]
PST - ppublish
SO  - Urology. 2001 Dec;58(6):1036-40. doi: 10.1016/s0090-4295(01)01459-5.