PMID- 11744784
OWN - NLM
STAT- MEDLINE
DCOM- 20020204
LR  - 20131121
IS  - 1355-4794 (Print)
IS  - 1355-4794 (Linking)
VI  - 7
IP  - 5
DP  - 2001
TI  - Amnesic syndrome and severe ataxia following the recreational use of 
      3,4-methylene-dioxymethamphetamine (MDMA, 'ecstasy') and other substances.
PG  - 423-32
AB  - A 26-year-old woman suffered disseminated intravascular coagulation (DIC) and a 
      brief respiratory arrest following recreational use of 
      3,4-methylene-dioxymethamphetamine (MDMA; 'ecstasy'), together with amyl nitrate, 
      lysergic acid (LSD), cannabis and alcohol. She was left with residual cognitive 
      and physical deficits, particularly severe anterograde memory disorder, mental 
      slowness, severe ataxia and dysarthria. Follow-up investigations have shown that 
      these have persisted, although there has been some improvement in verbal 
      recognition memory and in social functioning. Magnetic resonance imaging and 
      quantified positron emission tomography investigations have revealed: (i) severe 
      cerebellar atrophy and hypometabolism accounting for the ataxia and dysarthria; 
      (ii) thalamic, retrosplenial and left medial temporal hypometabolism to which the 
      anterograde amnesia can be attributed; and (iii) some degree of 
      fronto-temporal-parietal hypometabolism, possibly accounting for the cognitive 
      slowness. The putative relationship of these abnormalities to the direct and 
      indirect effects of MDMA toxicity, hypoxia and ischaemia is considered.
FAU - Kopelman, M D
AU  - Kopelman MD
AD  - Neuropsychiatry and Memory Disorders Clinic, University Department of Psychiatry 
      and Psychology, King's College, St Thomas's Campus, London SE1 7EH, UK. 
      michael.kopelman@kcl.a.cuk
FAU - Reed, L J
AU  - Reed LJ
FAU - Marsden, P
AU  - Marsden P
FAU - Mayes, A R
AU  - Mayes AR
FAU - Jaldow, E
AU  - Jaldow E
FAU - Laing, H
AU  - Laing H
FAU - Isaac, C
AU  - Isaac C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neurocase
JT  - Neurocase
JID - 9511374
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Amnesia/*chemically induced/diagnosis
MH  - Brain Mapping
MH  - Cerebellar Ataxia/*chemically induced/diagnosis
MH  - Disseminated Intravascular Coagulation/chemically induced/diagnosis
MH  - Drug Interactions
MH  - Female
MH  - Heart Arrest/chemically induced/diagnosis
MH  - Humans
MH  - Hypoxia, Brain/chemically induced/diagnosis
MH  - Magnetic Resonance Imaging
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Neuropsychological Tests
MH  - Substance-Related Disorders/*complications
MH  - Tomography, Emission-Computed
EDAT- 2001/12/18 10:00
MHDA- 2002/02/05 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/02/05 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - 10.1076/neur.7.5.423.16247 [doi]
PST - ppublish
SO  - Neurocase. 2001;7(5):423-32. doi: 10.1076/neur.7.5.423.16247.