PMID- 11744808
OWN - NLM
STAT- MEDLINE
DCOM- 20020716
LR  - 20180213
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 90
IP  - 1
DP  - 2002 Jan
TI  - The effect of renal transplantation on pulmonary function.
PG  - 72-7
AB  - In patients with chronic renal failure, mechanical and hemodynamic changes could 
      occur in the lungs without obvious pulmonary symptoms and findings and their 
      effects could pave the way to pulmonary functional disorders. In this study, 
      pulmonary functional disorders and especially alveolocapillary defects, which are 
      frequently seen in uremia, were determined in renal transplanted patients. 
      Pulmonary functions and diffusion capacity were assessed in uremic patients (n = 
      20) and in successfully transplanted patients (n = 20) without any lung disease 
      or pulmonary edema symptoms and findings. Patients were selected randomly among 
      outpatients who were followed up in a Nephrology and Transplantation Unit. Forced 
      vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and peak expiratory 
      flow (PEF25-75) were measured. Single breath carbon monoxide diffusion test and 
      diffusion lung capacity adjusted for hemoglobin concentration (DLAdj) were done. 
      The means of the spirometric values such as FVC, FEV1 and FEV1/FVC were normal in 
      the nondialyzed uremic group, but the PEF25-75 value (68.7%) and diffusion 
      capacity (DLAdj 72.7%) were found to be slightly low. There were 2 patients with 
      normal values and 18 patients with some functional abnormalities in this 
      nondialyzed uremic group. The means of all spirometric parameters and diffusion 
      capacities were found to be normal in the transplanted group. There were 7 
      patients with normal function and 13 patients with some functional abnormalities 
      in this transplanted group. When the nondialyzed uremic group and the 
      transplanted group were compared statistically, significant differences were 
      found between their spirometric values (except for FVC) and their diffusion 
      capacities. Even though the uremic patients did not show any symptoms, their 
      pulmonary function tests, especially diffusion capacity, were found to be 
      disturbed. Although the transplanted patients as a group had normal mean 
      spirometric values and diffusion capacity there were nevertheless many individual 
      transplanted patients with defective diffusion capacity and abnormal spirometric 
      values.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Kalender, Betul
AU  - Kalender B
AD  - Department of Nephrology, Cerrahpasa Medical Faculty, Istanbul University, 
      Istanbul, Turkey. bkalender@hotmail.com
FAU - Erk, Muzeyyen
AU  - Erk M
FAU - Pekpak, Meltem Ayaz
AU  - Pekpak MA
FAU - Apaydin, Suheyla
AU  - Apaydin S
FAU - Ataman, Rezzan
AU  - Ataman R
FAU - Serdengecti, Kamil
AU  - Serdengecti K
FAU - Sariyar, Muzaffer
AU  - Sariyar M
FAU - Erek, Ekrem
AU  - Erek E
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/*complications/surgery
MH  - *Kidney Transplantation
MH  - Lung/*physiology/physiopathology
MH  - Lung Diseases/*etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Diffusing Capacity
MH  - *Respiration
MH  - Respiratory Function Tests
MH  - Uremia/physiopathology
EDAT- 2001/12/18 10:00
MHDA- 2002/07/18 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/07/18 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - nef90072 [pii]
AID - 10.1159/000046317 [doi]
PST - ppublish
SO  - Nephron. 2002 Jan;90(1):72-7. doi: 10.1159/000046317.