PMID- 11745428
OWN - NLM
STAT- MEDLINE
DCOM- 20020107
LR  - 20220409
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 94
IP  - 3
DP  - 2001 Nov 1
TI  - Familial carcinoid tumors and subsequent cancers: a nation-wide epidemiologic 
      study from Sweden.
PG  - 444-8
AB  - Carcinoids are rare neuroendocrine tumors, mainly located in the bowel, stomach 
      and lung. Familial risks in carcinoid tumours are not well known apart from 
      multiple endocrine neoplasia 1 (MEN1). We used the nation-wide Swedish 
      Family-Cancer Database on 10.1 million individuals for assessment. Carcinoid 
      tumors were retrieved from the Cancer Registry covering the years 1958-1998. The 
      offspring generation, aged 0-66 years, accumulated 190 million person-years at 
      risk. The age-adjusted incidence rates were 0.76 for men and 1.29/100,000 for 
      women. Standardized incidence ratios (SIRs) were calculated for offspring when 
      their parents had a carcinoid or any other cancer. When parents presented with 
      carcinoids, SIRs for offspring were 4.35 (n = 8, 95% CI 1.86-7.89) for small 
      intestinal and 4.65 (n = 4, 95% CI 1.21-10.32) for colon carcinoids. If both 
      offspring and parents presented with small intestinal carcinoids, the SIR was 
      12.31 (n = 4, 95% CI 3.20-27.34). Offspring carcinoids were also increased if 
      parents presented with bladder and endocrine gland tumors, the latter association 
      probably partially due to MEN1. Risks for second cancers were increased, 
      particularly at sites where familial risks were found, including carcinoids in 
      the small intestine.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Hemminki, K
AU  - Hemminki K
AD  - Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.
FAU - Li, X
AU  - Li X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Carcinoid Tumor/epidemiology/*genetics/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Colonic Neoplasms/epidemiology
MH  - Databases as Topic
MH  - Endocrine Gland Neoplasms/epidemiology
MH  - Family Health
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Intestinal Neoplasms/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/epidemiology
MH  - Neoplasms/*epidemiology
MH  - Neoplasms, Second Primary/epidemiology
MH  - Recurrence
MH  - Risk Factors
MH  - Sex Factors
MH  - Sweden
MH  - Time Factors
MH  - Urinary Bladder Neoplasms/epidemiology
EDAT- 2001/12/18 10:00
MHDA- 2002/01/10 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/01/10 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - 10.1002/ijc.1473 [pii]
AID - 10.1002/ijc.1473 [doi]
PST - ppublish
SO  - Int J Cancer. 2001 Nov 1;94(3):444-8. doi: 10.1002/ijc.1473.