PMID- 11745656
OWN - NLM
STAT- MEDLINE
DCOM- 20020130
LR  - 20220310
IS  - 0022-3034 (Print)
IS  - 0022-3034 (Linking)
VI  - 49
IP  - 3
DP  - 2001 Nov 15
TI  - Developmental changes in BDNF protein levels in the hamster retina and superior 
      colliculus.
PG  - 173-87
AB  - Quantitative studies of ontogenetic changes in the levels of brain-derived 
      neurotrophic factor (BDNF) mRNA and its effector, BDNF protein, are not available 
      for the retinal projection system. We used an electrochemiluminescence 
      immunoassay to measure developmental changes in the tissue concentration of BDNF 
      within the hamster retina and superior colliculus (SC). In the SC, we first 
      detected BDNF (about 9 pg/mg tissue) on embryonic day 14 (E14). BDNF protein 
      concentration in the SC rises about fourfold between (E14) and postnatal day 4 
      (P4), remains at a plateau through P15, then declines by about one-third to 
      attain its adult level by P18. By contrast, BDNF protein concentration in the 
      retina remains low (about 1 pg/mg tissue) through P12, then increases 4.5-fold to 
      attain its adult level on P18. The developmental changes in retinal and 
      collicular BDNF protein concentrations are temporally correlated with multiple 
      events in the structural and functional maturation of the hamster retinal 
      projection system. Our data suggest roles for BDNF in the cellular mechanisms 
      underlying some of these events and are crucial to the design of experiments to 
      examine those roles.
CI  - Copyright 2001 John Wiley & Sons, Inc.
FAU - Frost, D O
AU  - Frost DO
AD  - Department of Pharmacology and Experimental Therapeutics, University of Maryland 
      School of Medicine, Baltimore, MD 21201, USA. dfrost@umaryland.edu
FAU - Ma, Y T
AU  - Ma YT
FAU - Hsieh, T
AU  - Hsieh T
FAU - Forbes, M E
AU  - Forbes ME
FAU - Johnson, J E
AU  - Johnson JE
LA  - eng
GR  - EY 11127/EY/NEI NIH HHS/United States
GR  - EY 11434/EY/NEI NIH HHS/United States
GR  - MH 49568/MH/NIMH NIH HHS/United States
GR  - NS 07375/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurobiol
JT  - Journal of neurobiology
JID - 0213640
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cricetinae
MH  - Eye Enucleation
MH  - Female
MH  - Immunoassay
MH  - Mesocricetus
MH  - Nerve Tissue Proteins/metabolism
MH  - Neural Pathways/physiology
MH  - Neurons/physiology
MH  - Pregnancy
MH  - Retina/cytology/*growth & development/*metabolism
MH  - Superior Colliculi/cytology/*growth & development/*metabolism
EDAT- 2001/12/18 10:00
MHDA- 2002/01/31 10:01
CRDT- 2001/12/18 10:00
PHST- 2001/12/18 10:00 [pubmed]
PHST- 2002/01/31 10:01 [medline]
PHST- 2001/12/18 10:00 [entrez]
AID - 10.1002/neu.1073 [pii]
AID - 10.1002/neu.1073 [doi]
PST - ppublish
SO  - J Neurobiol. 2001 Nov 15;49(3):173-87. doi: 10.1002/neu.1073.