PMID- 11748065
OWN - NLM
STAT- MEDLINE
DCOM- 20020124
LR  - 20220316
IS  - 0363-6135 (Print)
IS  - 0363-6135 (Linking)
VI  - 282
IP  - 1
DP  - 2002 Jan
TI  - Regional prolongation of ARI and altered restitution properties cause ventricular 
      arrhythmia in heart failure.
PG  - H212-8
AB  - The mechanism of arrhythmogenicity in heart failure remains poorly understood. We 
      examined the relationship between electrical abnormalities and ventricular 
      arrhythmia by using experimental heart failure models. Sixty unipolar 
      electrograms were recorded from the entire cardiac surface in control dogs (n = 
      13) and pacing-induced heart failure dogs (n = 16). In failing hearts, activation 
      time (AT) was delayed at the apex, and AT dispersion increased in failing hearts. 
      Activation-recovery intervals (ARI) were prolonged mainly at the apex and ARI 
      dispersion was significantly augmented. The slope of the ARI restitution curve, 
      interaction of diastolic interval, and ARI in failing hearts was significantly 
      steeper than in control hearts. Ventricular fibrillation (VF) was easily induced 
      by programmed stimulation in failing hearts, whereas no arrhythmia occurred in 
      control hearts. Computer simulation studies could reproduce the experimental 
      results. Altering the ARI restitution to the steep slope causes VF in a model 
      heart. It is suggested that electrical remodeling, especially steepness of 
      electrical restitution, may play a role in arrhythmogenicity in failing hearts.
FAU - Watanabe, Tetsu
AU  - Watanabe T
AD  - First Department of Internal Medicine, Yamagata University School of Medicine, 
      2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.
FAU - Yamaki, Michiyasu
AU  - Yamaki M
FAU - Yamauchi, Sou
AU  - Yamauchi S
FAU - Minamihaba, Osamu
AU  - Minamihaba O
FAU - Miyashita, Takehiko
AU  - Miyashita T
FAU - Kubota, Isao
AU  - Kubota I
FAU - Tomoike, Hitonobu
AU  - Tomoike H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
SB  - IM
MH  - Animals
MH  - Arrhythmias, Cardiac/*physiopathology
MH  - Blood Flow Velocity
MH  - Dogs
MH  - Electrocardiography
MH  - Heart Failure/*physiopathology
MH  - Heart Ventricles
MH  - Hemodynamics/*physiology
MH  - Reference Values
MH  - Time Factors
MH  - Ventricular Fibrillation/*physiopathology
EDAT- 2001/12/19 10:00
MHDA- 2002/01/25 10:01
CRDT- 2001/12/19 10:00
PHST- 2001/12/19 10:00 [pubmed]
PHST- 2002/01/25 10:01 [medline]
PHST- 2001/12/19 10:00 [entrez]
AID - 10.1152/ajpheart.2002.282.1.H212 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2002 Jan;282(1):H212-8. doi: 
      10.1152/ajpheart.2002.282.1.H212.